149934-51-0

Basic information

• Product Name: N-(4-cyanophenyl)-2,2-dimethylpropanamide
• Synonyms: N-(4-cyanophenyl)-2,2-dimethylpropanamide
• CAS NO: 149934-51-0
• Molecular Formula: C₁₂H₁₄N₂O
• Molecular Weight: 202.25236
• Mol File: 149934-51-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-cyanophenyl)-2,2-dimethylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-cyanophenyl)-2,2-dimethylpropanamide(149934-51-0)
• EPA Substance Registry System: N-(4-cyanophenyl)-2,2-dimethylpropanamide(149934-51-0)

Safety Data

• Hazardous Substances Data: 149934-51-0(Hazardous Substances Data)

Upstream product

• 77287-34-4 formamide 
• 159217-89-7 N-Boc-4-iodoaniline 
• 40465-45-0 p-cyanophenyl isocyanate 
• 75-98-9 Trimethylacetic acid 
• 3282-30-2 pivaloyl chloride 
• 873-74-5 4-Aminobenzonitrile 

Downstream Products

• 1240044-08-9 tert-butyl N-[4-(pivalamido)benzyl]carbamate 
• 6625-74-7 N-pivaloylaniline 
• 928649-23-4 4-(N-methyl-2,2-dimethyl-propionylamino)-benzonitrile 

Relevant articles and documents

A carboxamide is the cyanogen source of aromatic nitrile to the preparation method of the (by machine translation)

The invention discloses a method for preparing aromatic nitrile, is under the action of the nickel catalyst, in order to carboxamide is the cyanogen source, and with various substituents haloarene coupled reactions, preparing aromatic nitrile. The reaction temperature is 100 - 160 °C, the reaction time is 6 - 24 hours. It overcomes the traditional aromatic nitrile of the synthesis method operation of complex steps, requires the use of a toxic, more expensive, functionalization of the cyanogen source as the reaction raw material and the like. Compared with the traditional method, this method is simple to use cheap, green non-toxic of the formamide is cyano sources; without the need of external dehydrating agent, formamide in the nickel catalyst of the catalytic dehydration at the same time, with a nickel catalyst in coordination with the halogenated aromatic hydrocyanation, more economic, high-efficiency, environmental protection; at the same time the method exhibits good substrate universality, to air, moisture, light are not sensitive, high yield, product separation and purification is simple, with wide application. (by machine translation)

Rhodium(III)-catalysed, redox-neutral C(sp2)-H alkenylation using pivalimide as a directing group with internal alkynes

In the presence of [RhCp?Cl2]2, N-pivaloyl anilines react with internal alkynes to give the corresponding 2-alkenylpivalimides under redox neutral conditions through C-H activation. This redox neutral hydroarylation, which does not require an external organic acid, unlocks a regioselective synthetic route to 2-alkenyl anilines and is generally applicable to diversely substituted electron rich and electron poor pivalimides.

An alternative route for synthesis of o-trifluoroacetylanilines as useful fluorine-containing intermediates

A series of o-trifluoroacetyl aniline derivatives were synthesized in three steps. In this method, we first utilized trifluoroacetic anhydride to introduce trifluoroacetyl group to the ortho position of aniline with higher yield than that of some previously reported methods. In addition, the procedure is shown to be highly regiospecific. This type of compounds can be used as the key intermediates in the preparation of a variety of inhibitors of HIV reverse transcriptase which is an important pharmacological target of many anti-AIDS agents.