14994-17-3Relevant academic research and scientific papers
A Novel Route to 2-Arylquinolines: Reductive Cleavage of 2′-Nitroaryl-Δ2 -isoxazolines
Kamath, Prashantha,Viner, Russell C.,Smith, Stephen C.,Lal, Mukul
, p. 1341 - 1345 (2017)
A novel synthetic route for the synthesis of quinolines starting from Δ 2 -isoxazolines under reductive conditions is reported. The reductive cyclization to quinolines is achieved under both metal and metal-free conditions. The reaction proceeds via an intramolecular N-H?O hydrogen bond intermediate, accelerating the reductive cleavage 1000-fold (DFT calculations) in comparison with non-hydrogen bonded system.
