612-96-4Relevant articles and documents
Substrate-Tuned Domino Annulation for Selective Synthesis of Poly-substituted Benzo[ f]imidazo[2,1- a][2,7]naphthyridines and 3-Azaheterocyclic Substituted 2-Arylquinolines
Ying, Zhimin,Cen, Jie,Luo, Feng,Wu, You,Liu, Shuangrong,Chen, Wenteng,Shao, Jiaan,Yu, Yongping
, p. 4747 - 4755 (2021)
A domino annulation/oxidation of heterocyclic ketene aminals (HKAs) and 2-aminochalcones has been developed for the selective synthesis of poly-substituted benzo[f]imidazo[2,1-a][2,7]naphthyridines and 3-azaheterocyclic substituted 2-arylquinolines. These reactions proceed well under mild conditions without any additives. Plausible mechanisms for such a polycyclic ring system assembly were also proposed. Moreover, benzo[f]imidazo[2,1-a][2,7]naphthyridine 3g displayed a fluorescence effect, demonstrating the potential applications in organic optical materials.
Furfuryl vinyl ethers in [4+2]-cycloaddition reactions
Oparina,Vysotskaya,Stepanov,Ushakov,Apartsin,Gusarova,Trofimov
, (2017)
For the first time [4+2]-cycloaddition reactions were carried out between furfuryl vinyl ethers and typical dienophiles and heterodienes proceeding in uncatalyzed conditions and resulting in previously unknown heterocyclic systems containing either free v
Enantioselective Dearomative [3 + 2] Umpolung Annulation of N-Heteroarenes with Alkynes
Cui, Bing-Hui,Huang, Wen-Yu,Jia, Yi-Xia,Liang, Ren-Xiao,Liu, Hang,Liu, Jia-Liang,Wang, Qiang,Yang, Peng,Zhang, Xiao-Dong,Zhang, Yue-Yuan
, p. 1087 - 1093 (2022/02/09)
Enantioselective [3 + 2] annulation of N-heteroarenes with alkynes has been developed via a cobalt-catalyzed dearomative umpolung strategy in the presence of chiral ligand and reducing reagent. A variety of electron-deficient N-heteroarenes, including qui
A Domino Heck Coupling-Cyclization-Dehydrogenative Strategy for the One-Pot Synthesis of Quinolines
Ghora, Santanu,Satyanarayana, Gedu,Sreenivasulu, Chinnabattigalla
, (2021/10/21)
An efficient, one-pot, domino synthesis of quinolines via the coupling of iodoanilines with allylic alcohols facilitated by palladium catalysis is described. The overall synthetic process involves an intermolecular Heck coupling between 2-iodoanilines and allylic alcohols, intramolecular condensation of in situ generated ketones with an internal amine functional group, and a dehydrogenation sequence. Notably, this protocol occurs in water as a green solvent. Significantly, the method exhibits broad substrate scope and is applied for the synthesis of deuterated quinolines through a deuterium-exchange process.