149976-34-1Relevant articles and documents
Rational design, synthesis, and crystallographic analysis of a hydroxyethylene-based HIV-1 protease inhibitor containing a heterocyclic P1'-P2' amide bond isostere
Thompson,Murthy,Zhao,Winborne,Green,Fisher,DesJarlais,Tomaszek Jr.,Meek,Gleason,Abdel-Meguid
, p. 3100 - 3107 (1994)
The rational design and synthesis of a highly potent inhibitor of HIV-1 protease have been accomplished. The inhibitor, SB 206343, is based on a model derived from the structure of the MVT-101/HIV-1 protease complex and contains a 4(5)-acylimidazole ring