159949-20-9

Upstream product

• 149976-34-1 (2R,4S,5S)-2-benzyl-5-<(tert-butoxycarbonyl)amino>-4-(tert-butyldimethylsiloxy)-N-(isoxazol-4-yl)-6-phenylhexanamide 
• 98818-51-0 N-(1,1-dimethylethoxycarbonyl)-5(S)-amino-4(S)-(t-butyldimethylsilyloxy)-6-phenyl-2(R)-(phenylmethyl)hexanoic acid 

Downstream Products

• 1027237-71-3 {(1S,2S,4R)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxy)-4-[5-(1-hydroxy-propyl)-1H-imidazol-2-yl]-5-phenyl-pentyl}-carbamic acid tert-butyl ester 
• 541552-04-9 2-<(1R,3S,4S)-1-benzyl-4<(tert-butoxycarbonyl)amino>-3-(tert-butyldimethylsiloxy)-5-phenylpentyl>-5-(1-hydroxy-2-methylpropyl)imidazole 
• 1026865-88-2 {(1S,2S,4R)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxy)-4-[5-(1-hydroxy-butyl)-1H-imidazol-2-yl]-5-phenyl-pentyl}-carbamic acid tert-butyl ester 
• 150349-10-3 2-<(1R,3S,4S)-1-benzyl-4<(tert-butoxycarbonyl)amino>-3-(tert-butyldimethylsiloxy)-5-phenylpentyl>-5-(2-methylpropionyl)imidazole 
• 1027237-33-7 [(1S,2S,4R)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxy)-4-(5-butyryl-1H-imidazol-2-yl)-5-phenyl-pentyl]-carbamic acid tert-butyl ester 
• 1025963-84-1 [(1S,2S,4R)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxy)-5-phenyl-4-(5-propionyl-1H-imidazol-2-yl)-pentyl]-carbamic acid tert-butyl ester 
• 150348-85-9 [(1S,2S,4R)-1-Benzyl-2-hydroxy-4-(5-isobutyryl-1H-imidazol-2-yl)-5-phenyl-pentyl]-carbamic acid tert-butyl ester 
• 150349-13-6 2-<(1R,3S,4S)-4-amino-1-benzyl-3-hydroxy-5-phenylpentyl>-5-(2-methylpropionyl)imidazole 

Relevant academic research and scientific papers

Rational design, synthesis, and crystallographic analysis of a hydroxyethylene-based HIV-1 protease inhibitor containing a heterocyclic P1'-P2' amide bond isostere

The rational design and synthesis of a highly potent inhibitor of HIV-1 protease have been accomplished. The inhibitor, SB 206343, is based on a model derived from the structure of the MVT-101/HIV-1 protease complex and contains a 4(5)-acylimidazole ring