1500-76-1

Upstream product

• 108-91-8 cyclohexylamine 
• 126-81-8 dimedone 

Downstream Products

• 13932-53-1 ethyl hydrogen carbonate 
• 78477-01-7 2-(Ethoxycarbonyloxy)-3-cyclohexylamino-5,5-dimethyl-2-cyclohexen-1-on 
• 78477-06-2 2--6-hydroxy-4,4-dimethyl-2,5-cyclohexadien-1-on 
• 78477-00-6 2-(4-Nitrobenzoyloxy)-3-cyclohexylamino-5,5-dimethyl-2-cyclohexen-1-on 
• 78477-05-1 2--6-hydroxy-4,4-dimethyl-2,5-cyclohexadien-1-on 
• 62-23-7 4-nitro-benzoic acid 
• 102689-03-2 2-Bromo-3-cyclohexylamino-5,5-dimethyl-cyclohex-2-enone 
• 78476-98-9 2-Benzoyloxy-3-cyclohexylamino-5,5-dimethyl-2-cyclohexen-1-on 
• 78477-03-9 2-(Benzoylcyclohexylamino)-6-hydroxy-4,4-dimethyl-2,5-cyclohexadien-1-on 
• 65-85-0 benzoic acid 
• 1067646-98-3 1-cyclohexyl-6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione 
• 78476-96-7 2-<(4-Chlorbenzoyl)cyclohexylamino>-6-(4-chlorbenzoyloxy)-4,4-dimethyl-2,5-cyclohexadien-1-on 
• 78477-04-0 2-<(4-Chlorbenzoyl)cyclohexylamino>-6-hydroxy-4,4-dimethyl-2,5-cyclohexadien-1-on 
• 102689-08-7 Cyclohexyl-(4-methoxy-6,6-dimethyl-6,7-dihydro-5H-9-thia-1,3,10-triaza-anthracen-8-yl)-amine 

Relevant academic research and scientific papers

Continuous flow iodination using an automated computer-vision controlled liquid-liquid extraction system

A dynamic computer-vision control system incorporating open-source software technologies (Python, OpenCV) was used to automate a gravity based in-line liquid-liquid extraction during the iodination of enaminones in continuous flow. The system was able to cope with significant colouration of the organic reaction stream and with significant volume/flow changes in the aqueous and organic phase streams due to extraction of the water soluble acetonitrile co-solvent.

Continuous Flow Liquid-Liquid Separation Using a Computer-Vision Control System: The Bromination of Enaminones with N -Bromosuccinimide

Incorporating open-source software components (Python, OpenCV), a computer-vision system was used to control the interface level in a gravity-based inline liquid-liquid separation device. This was used in the continuous flow bromination of a series of enaminone substrates. The main byproduct of the reaction, succinimide, was efficiently extracted into the aqueous stream, providing clean products without the need for further purification.

FeCl3-Catalyzed Combinatorial Synthesis of Functionalized Spiro[Indolo-3,10′-indeno [1,2- b ]quinolin]-trione Derivatives

An efficient, inexpensive, environmentally friendly and high yield one-pot route to new spiro[indolo-3,10′-indeno [1,2-b]quinolin]-trione derivatives has been developed, involving three-component reaction of enaminones, N-substituted isatins and Indane-1,3-dione catalyzed by FeCl3. The approach to this spiro-heterocycle is noteworthy because it results in the formation of three new σ (two C-C and one C-N) bonds in a single operation, leading to the construction of novel spiro skeleton. This method works on a large scale in excellent yields.