15001-11-3

Basic information

• Product Name: ETHYL 5-AMINO-1-(4-METHYLPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE
• Synonyms: SALOR-INT L251453-1EA;ETHYL 5-AMINO-1-P-TOLYL-1H-PYRAZOLE-4-CARBOXYLATE;ETHYL 5-AMINO-1-P-TOLYLPYRAZOLE-4-CARBOXYLATE;ETHYL 5-AMINO-1-(4-METHYLPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE;BUTTPARK 20\09-21;AKOS BBS-00004493;5-AMINO-1-(4-METHYLPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;5-Amino-1-p-tolyl-1H-pyrazole-4-carboxylic acid ethyl ester
• CAS NO: 15001-11-3
• Molecular Formula: C₁₃H₁₅N₃O₂
• Molecular Weight: 245.28
• Mol File: 15001-11-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 114-116°C
• Boiling Point: 394.8 °C at 760 mmHg
• Flash Point: 192.5 °C
• Appearance: /
• Density: 1.23 g/cm³
• Vapor Pressure: 1.93E-06mmHg at 25°C
• Refractive Index: 1.6
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: ETHYL 5-AMINO-1-(4-METHYLPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 5-AMINO-1-(4-METHYLPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE(15001-11-3)
• EPA Substance Registry System: ETHYL 5-AMINO-1-(4-METHYLPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE(15001-11-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 15001-11-3(Hazardous Substances Data)

Usage

Description

ETHYL 5-AMINO-1-(4-METHYLPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE is a pyrazole derivative chemical compound characterized by the molecular formula C15H16N4O2. It features an ethyl ester group and an amino group attached to a 1,4-disubstituted phenyl ring, which endows it with unique biological activities and potential as a building block for the synthesis of bioactive molecules. Due to its properties, it holds promise in the pharmaceutical and agrochemical industries, although it requires careful handling and usage to mitigate any associated hazards.

Uses

Used in Pharmaceutical Industry:
ETHYL 5-AMINO-1-(4-METHYLPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE is used as a building block for the synthesis of bioactive molecules, leveraging its unique chemical structure to create new pharmaceutical compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, ETHYL 5-AMINO-1-(4-METHYLPHENYL)-1H-PYRAZOLE-4-CARBOXYLATE is utilized as a precursor in the development of new agrochemicals, potentially contributing to the creation of novel pesticides or other agricultural chemicals that can enhance crop protection and yield.

InChI:InChI=1/C13H15N3O2/c1-3-18-13(17)11-8-15-16(12(11)14)10-6-4-9(2)5-7-10/h4-8H,3,14H2,1-2H3

Upstream product

• 539-44-6 N-4-methylphenylhydrazine 
• 72459-84-8 ethyl (ethoxymethylene)cyanoacetate 
• 42466-67-1 ethyl (ethoxymethylene)cyanoacetate 
• 637-60-5 p-tolylhydrazine hydrochloride 
• 94-05-3 ethyl (ethoxymethylene)cyanoacetate 

Downstream Products

• 14678-93-4 5-amino-1-p-tolyl-1H-pyrazole-4-carboxylic acid 
• 14678-99-0 2-p-tolyl-2H-pyrazol-3-ylamine 

Relevant articles and documents

The optimization and characterization of functionalized sulfonamides derived from sulfaphenazole against Mycobacterium tuberculosis with reduced CYP 2C9 inhibition

In this study, a series of sulfonamide compounds was designed and synthesized through the systematic optimization of the antibacterial agent sulfaphenazole for the treatment of Mycobacterium tuberculosis (M. tuberculosis). Preliminary results indicate that the 4-aminobenzenesulfonamide moiety plays a key role in maintaining antimycobacterial activity. Compounds 10c, 10d, 10f and 10i through the optimization on phenyl ring at the R2 site on the pyrazole displayed promising antimycobacterial activity paired with low cytotoxicity. In particular, compound 10d displayed good activity (MIC = 5.69 μg/mL) with low inhibition of CYP 2C9 (IC50 > 10 μM), consequently low potential risk of drug-drug interaction. These promising results provide new insight into the combination regimen using sulfonamide as one component for the treatment of M. tuberculosis.

Novel coumarin-pyrazole carboxamide derivatives as potential topoisomerase II inhibitors: Design, synthesis and antibacterial activity

The identification of novel Topoisomerase II (Topo II) inhibitors is one of the most attractive directions in the field of bactericide research and development. In our ongoing efforts to pursue the class of inhibitors, six series of 70 novel coumarin-pyrazole carboxamide derivatives were designed and synthesized. As a result of the evaluation against four destructive bacteria, including Staphylococcus aureus, Listeria monocytogenes, Escherichia coli and Salmonella. Compound 8III-k (MIC = 0.25 mg/L) showed considerable inhibitory activity than ciprofloxacin (MIC = 0.5 mg/L) against Escherichia coli and 8V-c (MIC = 0.05 mg/L) exhibited excellent antibacterial activity than ciprofloxacin (MIC = 0.25 mg/L) against Salmonella. The selected compounds (8III-k, 8V-c and 8V-k) exhibit potent inhibition against Topo II and Topo IV with IC50 values (9.4–25 mg/L). Molecular docking model showed that the compounds 8V-c and 8V-k can bind well to the target by interacting with amino acid residues. It will provide some valuable information for the commercial Topo II inhibiting bactericides.

A clean and rapid synthesis of 5-aminopyrazole-4-carboxylic acid esters and nitriles using montmorillonite K10

A series of 5-aminopyrazole-4-carboxylates (4a-f) and nitriles (5a-f) have been synthesized under heterogeneous catalytic conditions using montmorillonite.