150026-75-8

Basic information

• Product Name: [R-(E)]-alpha-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methylethyl)benzenepropanol
• Synonyms: ALPHA-[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-2-(1-HYDROXY-1-METHYLETHYL)-,[R-(E)]-BENZENEPROPANOL;A-[3-[2-(7-Chloro-2-Quinolinyl)Ethenyl]Phenyl]-2-(1-Hydroxy-1-Methylethyl)-,[R-(E)]- Benzenepropanol;[R-(E)]-A-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methylethyl)benzenepropanol;[R-(E)]-alpha-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methylethyl)benzenepropanol;2-[3-(R)-[3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl]-3-hydroxypropyl]phenyl-2-propanol;(R)-α-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-Methylethyl)benzenepropanol;Montelukast (3R)-Hydroxy Propanol;[R-(E)]-alpha-[3-[2-(7-Chloro-2- quinolinyl)ethenyl]phenyl]-2- (1- hydroxy-1-Methylethyl) (2- benzenepropanol
• CAS NO: 150026-75-8
• Molecular Formula: C₂₉H₂₈ClNO₂
• Molecular Weight: 457.99
• Product Categories: Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 150026-75-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 78-83°C
• Boiling Point: 636.8 °C at 760 mmHg
• Flash Point: 338.9 °C
• Appearance: /
• Density: 1.244
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: [R-(E)]-alpha-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methylethyl)benzenepropanol(CAS DataBase Reference)
• NIST Chemistry Reference: [R-(E)]-alpha-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methylethyl)benzenepropanol(150026-75-8)
• EPA Substance Registry System: [R-(E)]-alpha-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methylethyl)benzenepropanol(150026-75-8)

Safety Data

• Hazardous Substances Data: 150026-75-8(Hazardous Substances Data)

Usage

Chemical Properties

Pale-Yellow Solid

Uses

Intermediate in the preparation of (S)-Montelukast.

Upstream product

• 1258428-71-5 trans-1-{3-[2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propan-1-one 
• 69352-05-2 2-(2-iodophenyl)propan-2-ol 
• 7073-69-0 2-(2-bromophenyl)propanol 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 88-67-5 2-Iodobenzoic acid 
• 88-65-3 2-bromobenzoic-acid 
• 676-58-4 methylmagnesium chloride 
• 150026-72-5 -2-<3-<3-<2-(7-chloro-2-quinolinyl)ethenyl>phenyl>-3-hydroxypropyl>benzoic acid methyl ester 

Downstream Products

• 920739-17-9 (S)-benzenepropanol α-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methyl ethyl)-α-methane sulfonate 

Relevant articles and documents

An enantioselective formal synthesis of montelukast sodium

A formal synthesis of the antiasthma drug montelukast sodium is described, wherein the key chiral diol intermediate was accessed with greater convergence of the C-C bond-forming steps as compared to previous routes. Improved synthetic efficiency was achie

Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists

Compounds having the formula I: STR1 are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.