15004-38-3

Basic information

• Product Name: 1-(2-chloroethyl)-3-tricyclo[3.3.1.1~3,7~]dec-1-ylurea
• CAS NO: 15004-38-3
• Molecular Formula: C₁₃H₂₁ClN₂O
• Molecular Weight: 256.7716
• Mol File: 15004-38-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 435.8°C at 760 mmHg
• Flash Point: 217.3°C
• Density: 1.2g/cm³
• Vapor Pressure: 8.54E-08mmHg at 25°C
• Refractive Index: 1.553
• CAS DataBase Reference: 1-(2-chloroethyl)-3-tricyclo[3.3.1.1~3,7~]dec-1-ylurea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chloroethyl)-3-tricyclo[3.3.1.1~3,7~]dec-1-ylurea(15004-38-3)
• EPA Substance Registry System: 1-(2-chloroethyl)-3-tricyclo[3.3.1.1~3,7~]dec-1-ylurea(15004-38-3)

Safety Data

• Hazardous Substances Data: 15004-38-3(Hazardous Substances Data)

Usage

General Description

The chemical 1-(2-chloroethyl)-3-tricyclo[3.3.1.1~3,7~]dec-1-ylurea, also known as Temozolomide, is an alkylating agent used in the treatment of certain types of cancer, particularly brain tumors. It works by interfering with the DNA replication process of cancer cells, ultimately leading to their death. Temozolomide is typically administered orally or intravenously and is commonly used in combination with other chemotherapy drugs. It is known for its efficacy in treating aggressive brain tumors such as glioblastoma multiforme. However, it can also cause serious side effects, including low blood cell counts and increased risk of infection, as well as potential long-term effects on the nervous system.

Upstream product

• 1943-83-5 2-chloroethyl isothiocyanate 
• 768-94-5 1-Adamantanamine 

Downstream Products

• 14039-10-2 C₁₃H₂₀ClN₃O₂ 
• 14973-23-0 N-Adamantan-1-yl-N'-<2-fluor-aethyl>-harnstoff 
• 14039-08-8 C₁₃H₂₀FN₃O₂ 

Relevant articles and documents

The synthesis of potential anticancer agents. XXXVI. N-nitrosoureas. II. Haloalkyl derivatives.

-