150174-93-9Relevant articles and documents
Efficient access to (1H)-isoindolin-1-one-3-carboxylic acid derivatives by orthopalladation and carbonylation of methyl arylglycinate substrates
Nieto, Sonia,Sayago, Francisco J.,Laborda, Pedro,Soler, Tatiana,Cativiela, Carlos,Urriolabeitia, Esteban P.
experimental part, p. 4185 - 4191 (2011/07/08)
The orthopalladation of methyl arylglycinate derivatives has been studied. The reaction proceeds efficiently for different electron-withdrawing and electron-releasing substituents at the aryl ring. The carbonylation of the orthopalladated complexes affords, in a single step, substituted (1H)-isoindolin-1-one-3-carboxylates. These compounds constitute valuable synthetic intermediates and can be transformed diastereoselectively into octahydroisoindole-1-carboxylic acid derivatives, an important scaffold in the synthesis of many biologically active compounds.
Chemistry of unprotected amino acids in aqueous solution: Direct bromination of aromatic amino acids with bromoisocyanuric acid sodium salt under strong acidic condition
Yokoyama, Yuusaku,Yamaguchi, Tomotsugu,Sato, Masanori,Kobayashi, Eri,Murakami, Yasuoki,Okuno, Hiroaki
, p. 1715 - 1719 (2007/10/03)
Brominations of unprotected aromatic amino acids such as phenylalanine, tyrosine, and glycine, with bromoisocyanuric acid mono sodium salt (BICA-Na) were conducted in 60% aq. H2SO4 at 0°C to give a mixture of mono-brominated products in good yield. Unexpectedly, meta-bromophenylglycine was obtained as main product accompanied by ortho- and para-substituted products, while phenylalanine gave only ortho- and para-substituted products. Bromination of 2-phenylethylamine or benzylamine showed a tendency similar to the corresponding amino acids.
Synthesis of Antiproteolytically Active Nα-Arylsulphonylated Amidinophenylglycinamides
Wagner, G.,Voigt, B.,Lischke, Ingrid
, p. 467 - 470 (2007/10/02)
Several Nα-arylsulphonylated p- and m-amidinophenylglycinamides were prepared for the purpose of testing their efficacy as serine proteinase inhibitors.These compounds were obtained from the bromophenylhydantoins 1 and 2 via the bromophenylglycines 3 and
