15020-57-2

Usage

Uses

Used in Pharmaceutical Synthesis:
P-HYDROXY-N,N-DIMETHYLBENZENE SULFONAMIDE is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its unique chemical structure allows it to be a key component in the synthesis of complex molecules with potential therapeutic applications.
Used in the Synthesis of Neuropeptide Y Y2 Receptor Antagonists:
P-HYDROXY-N,N-DIMETHYLBENZENE SULFONAMIDE is used as a reagent to synthesize N-(4-ethoxyphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide derivatives. These derivatives act as neuropeptide Y Y2 receptor antagonists, which have potential applications in the treatment of various neurological and psychiatric disorders, such as obesity, anxiety, and depression.

InChI:InChI=1/C8H11NO3S/c1-9(2)13(11,12)8-5-3-7(10)4-6-8/h3-6,10H,1-2H3

Upstream product

• 368-87-6 4-hydroxybenzene-1-sulfonyl fluoride 
• 124-40-3 dimethyl amine 
• 66950-63-8 phenyl N,N-dimethylsulfamate 
• 4025-67-6 4-hydroxybenzene-1-sulfonyl chloride 
• 825-90-1 sodium p-hydroxybenzenesulfonate 
• 59907-37-8 N,N-dimethyl-4-methoxybenzenesulfonamide 
• 79119-26-9 4-acetoxybenzenesulfonyl chloride 
• 506-59-2 N,N-dimethylammonium chloride 
• 383-31-3 4-fluoro-1-(N,N-dimethylaminosulfonyl)benzene 
• 7463-22-1 N,N-Dimethyl-p-chlorobenzenesulfonamide 

Downstream Products

• 59907-37-8 N,N-dimethyl-4-methoxybenzenesulfonamide 
• 41989-56-4 Isopropoxymethyl-phosphonothioic acid O-(4-dimethylsulfamoyl-phenyl) ester O-ethyl ester 
• 41990-27-6 Methoxymethyl-phosphonothioic acid O-(4-dimethylsulfamoyl-phenyl) ester O-ethyl ester 
• 41990-33-4 Methoxymethyl-phosphonothioic acid O-(4-dimethylsulfamoyl-phenyl) ester O-methyl ester 
• 51005-99-3 Methoxymethyl-phosphonic acid 4-dimethylsulfamoyl-phenyl ester ethyl ester 
• 42247-91-6 4-hydroxy-N,N-dimethyl-3-nitrobenzenesulfonamide 
• 76472-25-8 p-(p-Guanidinobenzoyloxy)-N,N-dimethylbenzenesulfonamide methanesulfonic acid salt 
• 1383479-24-0 C₂₇H₃₀N₂O₅S 
• 32547-91-4 N,N-dimethyl-4-(prop-2-ynyloxy)benzenesulfonamide 
• 61712-33-2 2,6-Dibromo-N,N-dimethyl-1-phenol-4-sulfonamide, propionate 
• 1196485-25-2 4-[4-(4-dimethylsulfamoyl-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester 
• 30989-03-8 2-chloro-N,N-dimethyl-1-phenol-4-sulfonamide 
• 61712-32-1 2,6-dichloro-N,N-dimethyl-1-phenol-4-sulfonamide 
• 31972-17-5 2,6-dibromo-N,N-dimethyl-1-phenol-4-sulfonamide 

Relevant academic research and scientific papers

A new synthetic route to aryl hydroxysulfonamides via a novel Fries-type rearrangement of aryl N,N-dialkylsulfamates

A novel thia-Fries rearrangement of sulfamates 1 in AlCl3 giving good yields of para-2 and ortho-3 arylhydroxysulfonamides offers a new and efficient route to these sulfonamides.

Practical sulfonylation of amines with 4-hydroxybenzenesulfonyl chloride: In situ silylation-desilylation

A one-pot procedure for the efficient sulfonylation of amines with 4-hydroxybenzenesulfonyl chloride involving in situ protection and deprotection of the phenol with N,O-bis(trimethylsilyl)acetamide (BTSA) is presented.

INDOLE AND AZAINDOLE HALOALLYLAMINE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF

The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as i

Synthesis and SAR of selective small molecule neuropeptide y Y2 receptor antagonists

Highly potent and selective small molecule neuropeptide Y Y2 receptor antagonists are reported. The systematic SAR exploration of a hit molecule N-(4-ethoxyphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide, identified from HTS, led to the discovery of highly potent NPY Y2 antagonists 16 (CYM 9484) and 54 (CYM 9552) with IC50 values of 19 nM and 12 nM respectively.

[1,2,4]-Triazolo[1,5-a]and pyrazolo[2,3-a][1,3,5]triazine derivatives

The invention concerns novel, pharmaceutically useful compounds of formula I in which Q is a 5-membered heteroaryl optionally bearing 1 or 2 substituents independently selected from (1-4C)alkyl and halogeno; R1 is hydrogen, (1-6C)alkyl, or (1-4

Benzopyran derivatives and processes for preparation thereof

Benzopyrene derivatives effective for the treatment of hypertension have been prepared.