66950-63-8

Basic information

• Product Name: Sulfamic acid, dimethyl-, phenyl ester
• CAS NO: 66950-63-8
• Molecular Formula: C8H11NO3S
• Molecular Weight: 201.246
• Mol File: 66950-63-8.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Sulfamic acid, dimethyl-, phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Sulfamic acid, dimethyl-, phenyl ester(66950-63-8)
• EPA Substance Registry System: Sulfamic acid, dimethyl-, phenyl ester(66950-63-8)

Safety Data

• Hazardous Substances Data: 66950-63-8(Hazardous Substances Data)

Upstream product

• 16475-29-9 phenylchlorosulfate 
• 75-50-3 trimethylamine 
• 19792-91-7 phenyl sulfamate 
• 74-88-4 methyl iodide 
• 139-02-6 sodium phenoxide 
• 13360-57-1 dimethylamino sulfonyl chloride 
• 108-95-2 phenol 
• 75-89-8 2,2,2-trifluoroethanol 
• 78162-61-5 phenyl betylate triflate 

Downstream Products

• 15020-57-2 N,N-dimethyl-4-hydroxybenzenesulfonamide 
• 30988-90-0 2-hydroxy-N,N-dimethylbenzenesulfonamide 
• 613-37-6 4-methoxylbiphenyl 
• 4096-20-2 N-phenyl piperidine 
• 92-53-5 4-Phenylmorpholine 
• 682773-53-1 1-phenyl-4-(pyridine-2-yl) piperazine 
• 436800-48-5 (9-ethyl-9H-carbazol-3-yl)-phenyl-amine 
• 1201594-21-9 C₈H₁₀FNO₃S 
• 1250999-09-7 4-(2-fluoro-4-iodophenyl)morpholine 
• 165800-03-3 linezolid 
• 168828-84-0 (R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one 
• 122-39-4 diphenylamine 
• 4058-04-2 N-phenyl-2,6-dimethylaniline 
• 552-82-9 benzhydrylidene(methyl)amine 

Relevant articles and documents

N -Arylation of (hetero)arylamines using aryl sulfamates and carbamates via C-O bond activation enabled by a reusable and durable nickel(0) catalyst

An effective and general aryl amination protocol has been developed using a magnetically recoverable Ni(0) based nanocatalyst. This new stable catalyst was prepared on Fe3O4@SiO2 modified by EDTA and investigated by FT-IR, EDX, TEM, XRD, DLS, FE-SEM, XPS, NMR, TGA, VSM, ICP and elemental analysis techniques. The reaction proceeded via carbon-oxygen bond cleavage of (hetero)aryl carbamates and sulfamates under simple and mild conditions without the use of any external ligands. This method demonstrated functional group tolerance in the N-arylation of various nitrogen-containing compounds as well as aliphatic amines, anilines, pyrroles, pyrazoles, imidazoles, indoles, and indazoles with good to excellent yields. Furthermore, the catalyst could be easily recovered by using an external magnetic field and directly reused at least six times without notable reduction in its activity. This journal is

Nickel-catalyzed amination of aryl sulfamates

Broad in scope: The first amination of aryl sulfamates, which are attractive cross-coupling partners, particularly for multistep syntheses, was achieved by using a nickel catalyst. The method provides a versatile means to use simple derivatives of phenol as precursors to polysubstituted aryl amines, as exemplified by a concise synthesis of the antibacterial drug linezolid (see scheme).

Sulfamates as antiglaucoma agents

Sulfamate esters of the formula where A is aryloxyalkyl, p is the number of unreacted hydroxy groups present on the alkyl moiety and may be zero, z is the number of --OS(O)2 NR1 R2 groups attached to carbons of the alkyl moiety and is always at least one; R1 and R2 are selected from hydrogen, loweralkyl, carboxy, and the like are useful in treating glaucoma.