13575-72-9

Basic information

• Product Name: 2-Aminoindan-1-ol
• Synonyms: 2-Amino-1-hydroxyindane;2-Aminoindan-1-ol, 2-Amino-2,3-dihydro-1H-inden-1-ol
• CAS NO: 13575-72-9
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149.19
• EINECS: 239-107-4
• Mol File: 13575-72-9.mol
• Article Data: 10

Chemical Properties

• Melting Point: 105-106 °C
• Boiling Point: 296.9°Cat760mmHg
• Flash Point: 133.4°C
• Appearance: /
• Density: 1.212g/cm³
• Vapor Pressure: 0.000626mmHg at 25°C
• Refractive Index: 1.626
• PKA: 13.85±0.40(Predicted)
• CAS DataBase Reference: 2-Aminoindan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Aminoindan-1-ol(13575-72-9)
• EPA Substance Registry System: 2-Aminoindan-1-ol(13575-72-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 13575-72-9(Hazardous Substances Data)

Usage

General Description

2-Aminoindan-1-ol, also known as 1-Amino-2-hydroxy-2,3-dihydro-1H-inden-2-ol, is a chemical compound with the molecular formula C9H11NO. It is a white crystalline solid that is used as a building block in the synthesis of various pharmaceuticals and organic compounds. 2-Aminoindan-1-ol has potential applications in the pharmaceutical industry due to its ability to act as a chiral building block for the synthesis of various biologically active molecules. It has also been studied for its potential neuroprotective properties in the treatment of neurodegenerative diseases. The compound is considered to be of low toxicity, but further research is needed to fully understand its potential applications and effects.

InChI:InChI=1/C9H11NO/c10-8-5-6-3-1-2-4-7(6)9(8)11/h1-4,8-9,11H,5,10H2

Upstream product

• 15028-10-1 indan-1,2-dione-2-oxime 
• 13575-71-8 trans-2-Acetamidoindanol-⁽¹⁾ 
• 83-33-0 inden-1-one 
• 95-13-6 1-indene 
• 86288-37-1 trans-1-azido-2-bromoindane 
• 13943-70-9 2-nitro-2,3-dihydro-1H-inden-1-one 
• 26976-63-6 2-amino-1-indanone 
• 26536-31-2 indano<1,2-b>aziridine 
• 1775-27-5 2-bromoindanone 
• 74036-09-2 2-(1-oxo-indan-2-yl)-isoindole-1,3-dione 
• 29365-64-8 (1R,2R)-(-)-2-phthalimidoindan-1-ol 
• 171285-94-2 (1R,2R)-2-azido-2,3-dihydro-1H-inden-1-yl-4-nitrobenzoate 
• 166942-30-9 (1S,2R)-2-azido-2,3-dihydro-1H-inden1-ol 
• 2338-18-3 2-aminoindane hydrochloride 

Downstream Products

• 13575-72-9 (1R,2R)-trans-2-amino-1-indanol 
• 94077-04-0 (1R,2R)-2-{[1-(2,3-Dimethoxy-phenyl)-meth-(E)-ylidene]-amino}-indan-1-ol 
• 144285-04-1 (1R,2R)-2-(2-hydroxybenzylideneamino)-1-indanol 
• 94077-02-8 (1R,2R)-2-{[1-Phenyl-meth-(E)-ylidene]-amino}-indan-1-ol 
• 23672-01-7 (+/-)-trans-2-Benzylamino-indanol-⁽¹⁾ 
• 94077-19-7 (1R,2R)-2-(2,3-Dimethoxy-benzylamino)-indan-1-ol 
• 94077-17-5 (1R,2R)-2-(3-Methoxy-benzylamino)-indan-1-ol 
• 23672-01-7 (-)-(1R,2R)-2-benzylaminoindan-1-ol 
• 144285-04-1 (1S,2S)-2-(2-hydroxybenzylideneamino)-1-indanol 
• 94077-03-9 (1R,2R)-2-{[1-(3-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-indan-1-ol 

Relevant articles and documents

Synthesis of cis- and trans-2-amino-1-indanoles

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Efficient preparation of biologically important 1,2-amino alcohols

An efficient three-step methodology developed for the preparation of 1,2-amino alcohols. In the first step a rapid coupling between bromoketones and potassium phthalimide in ionic liquid produced-phthalimido ketones in quantitative yields, which is followed by a facile reduction using NaCNBH 3 in acetic acid to give corresponding phthalimido alcohols and finally effecting hydrazinolysis in water at 60C to yield biologically important 1,2-amino alcohols.

Stereoselective synthesis of 1,2-amino alcohols by asymmetric borane reduction of α-oxoketoxime ethers

Asymmetric reduction of α-oxoketoxime ethers with the reagents prepared in situ from trimethyl borate and chiral amino alcohols derived from either L-proline or α-pinene was investigated. Both cyclic and acyclic α- oxoketoxime ethers were reduced to afford the corresponding chiral 1,2amino alcohols with high enantioselectivities.