1503-54-4

Usage

Uses

Used in Organic Synthesis:
O-acetyl-5-iodosalicylic acid is utilized as a reagent in the synthesis of pharmaceutical compounds and other organic molecules, contributing to the development of new chemical entities with potential therapeutic and industrial applications.
Used in Medicinal Chemistry:
O-acetyl-5-iodosalicylic acid is employed as a key intermediate in the design and synthesis of new drugs, leveraging its unique structural features and reactivity to create novel pharmaceutical agents with improved efficacy and selectivity.
Used in Antimicrobial Applications:
O-acetyl-5-iodosalicylic acid is used as an antimicrobial agent, exhibiting activity against various microorganisms. Its iodinated structure and acetyl group may contribute to its antimicrobial properties, making it a potential candidate for the development of new antimicrobial drugs and treatments.
Used in Antioxidant Applications:
Due to its antioxidant properties, O-acetyl-5-iodosalicylic acid is used as a protective agent against oxidative stress and damage in various biological systems. It may have potential applications in the development of antioxidants for use in pharmaceuticals, nutraceuticals, and other health-related products.
Used in Pharmaceutical Development:
O-acetyl-5-iodosalicylic acid is used as a starting material or intermediate in the development of new pharmaceuticals, taking advantage of its chemical properties to create innovative drug candidates with diverse therapeutic applications.

InChI:InChI=1/C9H7IO4/c1-5(11)14-8-3-2-6(10)4-7(8)9(12)13/h2-4H,1H3,(H,12,13)

Upstream product

• 119-30-2 2-hydroxy-5-iodobenzoic acid 
• 108-24-7 acetic anhydride 
• 89-57-6 5-Aminosalicylic Acid 

Downstream Products

• 5538-54-5 2-acetoxy-5-iodo-benzoyl chloride 
• 102297-97-2 3-acetyl-2-hydroxy-5-iodobenzoic acid 
• 367526-64-5 diethyl 2-{hydroxy[5-iodo-2-(acetoxy)phenyl]methylene}malonate 
• 18179-40-3 2-hydroxy-5-iodobenzamide 

Relevant academic research and scientific papers

A highly practical route to 2-methylchromones from 2-acetoxybenzoic acids

2-Methylchromones were accessed via a keto ester condensation on 2-acetoxybenzoyl chloride, followed by cyclization and decarboxylation. No column chromatography was required in the process.

Novel quinolizidine salicylamide influenza fusion inhibitors

A novel series of quinolizidine salicylamides was synthesized as specific inhibitors of the H1 subtype of influenza A viruses. These inhibitors inhibit the pH-induced fusion process, thereby blocking viral entry into host cells. Compound 16 was the most active inhibitor in this series with an EC50 of 0.25 μg/mL in plaque reduction assay. The synthesis and the SAR of these compounds are discussed.

Synthesis and biological activity of novel 1,3-benzoxazine derivatives as K+ channel openers

A new series of 1,3-benzoxazine derivatives with a 2-pyridine 1-oxide group at C4 was designed to explore novel K+ channel openers. Synthesis was carried out by using a palladium(0)-catalyzed carbon-carbon bond formation reaction of imino-triflates with organozinc reagents and via a new one-pot 1,3-benzoxazine skeleton formation reaction of benzoylpyridines. The compounds were tested for vasorelaxant activity in tetraethylammonium chloride (TEA) and BaCl2-induced and high KCl-induced contraction of rat aorta to identify potential K+ channel openers, and also for oral hypotensive effects in spontaneously hypertensive rats. An electron- withdrawing group with the proper shape at C6 and a methyl or halogens group at C7 of the 1,3-benzoxazine nucleus were required for the development of optimal vasorelaxant and hypotensive activity. In particular, 2-(6-bromo-7- chloro-2,2-dimethyl-2H-1,3-benzoxazin-4-yl)pyridine 1-oxide (71) showed more potent vasorelaxant activity (EC50=0.14 μM) against TEA and BaCL2- induced contraction and longer-lasting hypotensive effects than cromakalim (1).