18179-40-3

Basic information

• Product Name: 2-HYDROXY-5-IODOBENZAMIDE
• Synonyms: 5-IODOSALICYLAMIDE;2-HYDROXY-5-IODOBENZAMIDE
• CAS NO: 18179-40-3
• Molecular Formula: C₇H₆INO₂
• Molecular Weight: 263.03
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds;Anilines, Amides & Amines;Iodine Compounds
• Mol File: 18179-40-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-HYDROXY-5-IODOBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-5-IODOBENZAMIDE(18179-40-3)
• EPA Substance Registry System: 2-HYDROXY-5-IODOBENZAMIDE(18179-40-3)

Safety Data

• Hazardous Substances Data: 18179-40-3(Hazardous Substances Data)

Usage

General Description

2-hydroxy-5-iodobenzamide is a chemical compound that belongs to the class of benzamides. It is composed of a benzene ring with a hydroxyl and iodine substituent at the 2nd and 5th position, respectively, and an amide functional group. 2-hydroxy-5-iodobenzamide is used in organic synthesis and pharmaceutical research due to its potential biological activities. It has been studied for its potential as a monoamine oxidase inhibitor, which could be useful in the treatment of neurological disorders and depression. Additionally, 2-hydroxy-5-iodobenzamide has been investigated for its anti-inflammatory and anticancer properties. Overall, this compound has garnered interest for its potential applications in the pharmaceutical industry.

Upstream product

• 5538-54-5 2-acetoxy-5-iodo-benzoyl chloride 
• 4068-75-1 methyl 5-iodosalicylate 
• 1503-54-4 2-acetoxy-5-iodobenzoic acid 
• 119-30-2 2-hydroxy-5-iodobenzoic acid 

Relevant articles and documents

Amidation of esters assisted by Mg(OCH3)2 or CaCl2

Magnesium methoxide (Mg(OCH3)2) and calcium chloride have been shown to facilitate the direct aminolysis of esters by ammonia to primary amides. Methyl, ethyl, isopropyl, and tert-butyl esters were converted to the corresponding carboxamides in good yields. Reactions have been run on a larger scale and without the safety liability inherent in the use of magnesium nitride (Mg3N2). Ammonium chloride and amine hydrochlorides have been used successfully in the place of ammonia with magnesium methoxide.

Synthesis and biological activity of novel 1,3-benzoxazine derivatives as K+ channel openers

A new series of 1,3-benzoxazine derivatives with a 2-pyridine 1-oxide group at C4 was designed to explore novel K+ channel openers. Synthesis was carried out by using a palladium(0)-catalyzed carbon-carbon bond formation reaction of imino-triflates with organozinc reagents and via a new one-pot 1,3-benzoxazine skeleton formation reaction of benzoylpyridines. The compounds were tested for vasorelaxant activity in tetraethylammonium chloride (TEA) and BaCl2-induced and high KCl-induced contraction of rat aorta to identify potential K+ channel openers, and also for oral hypotensive effects in spontaneously hypertensive rats. An electron- withdrawing group with the proper shape at C6 and a methyl or halogens group at C7 of the 1,3-benzoxazine nucleus were required for the development of optimal vasorelaxant and hypotensive activity. In particular, 2-(6-bromo-7- chloro-2,2-dimethyl-2H-1,3-benzoxazin-4-yl)pyridine 1-oxide (71) showed more potent vasorelaxant activity (EC50=0.14 μM) against TEA and BaCL2- induced contraction and longer-lasting hypotensive effects than cromakalim (1).