18179-40-3

Usage

Uses

Used in Pharmaceutical Research:
2-hydroxy-5-iodobenzamide is used as a monoamine oxidase inhibitor for its potential in treating neurological disorders and depression. Its ability to inhibit monoamine oxidase enzymes could help regulate neurotransmitter levels, offering therapeutic benefits.
Used in Organic Synthesis:
In the field of organic synthesis, 2-hydroxy-5-iodobenzamide is utilized as a key intermediate or building block in the development of various pharmaceutical compounds, contributing to the synthesis of new drugs with potential therapeutic applications.
Used in Anti-inflammatory Applications:
2-hydroxy-5-iodobenzamide is studied for its anti-inflammatory properties, which could be beneficial in managing inflammation-related conditions. Its potential to modulate inflammatory responses may lead to the development of new treatments for inflammatory diseases.
Used in Anticancer Applications:
2-hydroxy-5-iodobenzamide has been investigated for its anticancer properties, showing promise in the development of cancer therapeutics. Its potential to target cancer cells and inhibit their growth makes it a candidate for further research and development in oncology.
Overall, 2-hydroxy-5-iodobenzamide's diverse applications in pharmaceutical research, organic synthesis, anti-inflammatory treatments, and anticancer therapies highlight its potential as a valuable compound in the medical and chemical fields.

Upstream product

• 5538-54-5 2-acetoxy-5-iodo-benzoyl chloride 
• 119-30-2 2-hydroxy-5-iodobenzoic acid 
• 4068-75-1 methyl 5-iodosalicylate 
• 1503-54-4 2-acetoxy-5-iodobenzoic acid 

Relevant academic research and scientific papers

Amidation of esters assisted by Mg(OCH3)2 or CaCl2

Magnesium methoxide (Mg(OCH3)2) and calcium chloride have been shown to facilitate the direct aminolysis of esters by ammonia to primary amides. Methyl, ethyl, isopropyl, and tert-butyl esters were converted to the corresponding carboxamides in good yields. Reactions have been run on a larger scale and without the safety liability inherent in the use of magnesium nitride (Mg3N2). Ammonium chloride and amine hydrochlorides have been used successfully in the place of ammonia with magnesium methoxide.

Magnesium nitride as a convenient source of ammonia: Preparation of primary amides

(Chemical Equation Presented) The use of magnesium nitride (Mg 3N2) as a convenient source of ammonia has been explored for the direct transformation of esters to primary amides. Methyl, ethyl, isopropyl, and tert-butyl esters are converted to the corresponding carboxamides in good yields (75-99%).

Synthesis and biological activity of novel 1,3-benzoxazine derivatives as K+ channel openers

A new series of 1,3-benzoxazine derivatives with a 2-pyridine 1-oxide group at C4 was designed to explore novel K+ channel openers. Synthesis was carried out by using a palladium(0)-catalyzed carbon-carbon bond formation reaction of imino-triflates with organozinc reagents and via a new one-pot 1,3-benzoxazine skeleton formation reaction of benzoylpyridines. The compounds were tested for vasorelaxant activity in tetraethylammonium chloride (TEA) and BaCl2-induced and high KCl-induced contraction of rat aorta to identify potential K+ channel openers, and also for oral hypotensive effects in spontaneously hypertensive rats. An electron- withdrawing group with the proper shape at C6 and a methyl or halogens group at C7 of the 1,3-benzoxazine nucleus were required for the development of optimal vasorelaxant and hypotensive activity. In particular, 2-(6-bromo-7- chloro-2,2-dimethyl-2H-1,3-benzoxazin-4-yl)pyridine 1-oxide (71) showed more potent vasorelaxant activity (EC50=0.14 μM) against TEA and BaCL2- induced contraction and longer-lasting hypotensive effects than cromakalim (1).