15030-91-8Relevant academic research and scientific papers
Impact of Dehydroamino Acids on the Structure and Stability of Incipient 310-Helical Peptides
Joaquin, Daniel,Lee, Michael A.,Kastner, David W.,Singh, Jatinder,Morrill, Shardon T.,Damstedt, Gracie,Castle, Steven L.
, p. 1601 - 1613 (2019/12/02)
A comparative study of the impact of small, medium-sized, and bulky α,β-dehydroamino acids (AAs) on the structure and stability of Balaram's incipient 310-helical peptide (1) is reported. Replacement of the N-terminal Aib residue of 1 with a AA
Synthesis and pharmacological evaluation of glycine-modified analogues of the neuroprotective agent glycyl-L-prolyl-L-glutamic acid (GPE)
Lai, Michelle Y.H.,Brimble, Margaret A.,Callis, David J.,Harris, Paul W.R.,Levi, Mark S.,Sieg, Frank
, p. 533 - 548 (2007/10/03)
The synthesis of 10 G*PE analogues, wherein the glycine residue has been modified, is described by coupling readily accessible dibenzyl-l-prolyl-l- glutamate 2 with various analogues of glycine. Pharmacological evaluation of the novel compounds was undertaken to further understand the role of the glycine residue on the observed neuroprotective properties of the endogenous tripeptide GPE.
CF3-BOP, CF3-PyBOP and CF3-HBTU: New peptide coupling reagents specially suited for α-aminoisobutyric acid condensations
Wijkmans, Jac C. H. M.,Kruijtzer, John A. W.,Marel, Gijs A. van der,Boom, Jacques H. van,Bloemhoff, Wim
, p. 394 - 397 (2007/10/02)
The peptide-coupling reagents CF3-BOP (1b), CF3-PyBOP (1c) and CF3-HBTU (2a) with built-in 1-hydroxy-6-(trifluoromethyl)benzotriazole proved to be highly efficient for the coupling of α-aminoisobutyric acid residues.
SYNTHESE VON 2-METHYLALANIN-PEPTIDEN, DIE pH-ABHAENGIGKEIT IHRER 13C-NMR-SPECTREN UND EINE NEUE METHODE ZUR AUSWERTUNG UEBER CS-DIAGRAMME
Leibfritz, Dieter,Haupt, Erhard,Dubischar, Norbert,Lachmann, Heinrich,Oekonomopulos, Raymond,Jung, Guenther
, p. 2165 - 2182 (2007/10/02)
The uncommon amino-acid 2-methylalanine (α-aminoisobutiryc acid, Aib) was investigated by 13C-NMR.The chemical shifts of amino- or carboxy-protected derivates of Aib and of protected oligopeptides are discussed with respect to neighbouring groups and amino acids.The pH-dependence of the 13C-NMR spectra of Aib, Aib-Ala, Ala-Aib, Aib-Ala-Aib and Aib-Ala-Aib-Ala-Aib was studied.Using these examples, a new and advantageous method is demonstrated for the first time for the evaluation of NMR titration curves, which uses so-called chemical shift diagrams (CS diagrams).
SOLUTION PHASE SYNTHESIS OF ALAMETHICIN I
Nagaraj, R.,Balaram, P.
, p. 1263 - 1270 (2007/10/02)
The total synthesis of alamethicin I by solution phase methods is reported.
