58281-75-7Relevant academic research and scientific papers
A kinetic method for detecting intramolecular peptide H-bonds
Banerjee, Shreya,Prabhakaran, Erode N.,Reddy, Damodara N.
, p. 15887 - 15891 (2021/09/22)
The current method for the detection of peptide hydrogen bond (PHB) formation places charge donors/acceptors (D/A) at the N-/C-termini of the peptides involved in the putative PHB. The efficiency of the charge transfer influences the kinetics of the first order reaction at A and hence reports on the formation and electronic properties of the PHB.
Impact of Dehydroamino Acids on the Structure and Stability of Incipient 310-Helical Peptides
Joaquin, Daniel,Lee, Michael A.,Kastner, David W.,Singh, Jatinder,Morrill, Shardon T.,Damstedt, Gracie,Castle, Steven L.
, p. 1601 - 1613 (2019/12/02)
A comparative study of the impact of small, medium-sized, and bulky α,β-dehydroamino acids (AAs) on the structure and stability of Balaram's incipient 310-helical peptide (1) is reported. Replacement of the N-terminal Aib residue of 1 with a AA
Synthesis and pharmacological evaluation of glycine-modified analogues of the neuroprotective agent glycyl-L-prolyl-L-glutamic acid (GPE)
Lai, Michelle Y.H.,Brimble, Margaret A.,Callis, David J.,Harris, Paul W.R.,Levi, Mark S.,Sieg, Frank
, p. 533 - 548 (2007/10/03)
The synthesis of 10 G*PE analogues, wherein the glycine residue has been modified, is described by coupling readily accessible dibenzyl-l-prolyl-l- glutamate 2 with various analogues of glycine. Pharmacological evaluation of the novel compounds was undertaken to further understand the role of the glycine residue on the observed neuroprotective properties of the endogenous tripeptide GPE.
SOLUTION PHASE SYNTHESIS OF ALAMETHICIN I
Nagaraj, R.,Balaram, P.
, p. 1263 - 1270 (2007/10/02)
The total synthesis of alamethicin I by solution phase methods is reported.
