150368-48-2

Upstream product

• 19064-14-3 2,6-Difluorobenzoic acid,ethyl ester 
• 150368-34-6 2-Butyl-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]oxy]quinoxaline 
• 150368-49-3 2-methyl-1-(1-oxopropoxy)propyl-2-butyl-6-ethoxy-3-<<2'-1H-tetrazol-5-yl<1,1'-biphenyl>-4-yl>oxy>-5-quinoxalinecarboxylate 
• 18063-02-0 2,6-difluorobenzoylchloride 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 150368-30-2 4-<2-(1H-tetrazol-5-yl)phenyl>phenol 
• 150368-44-8 2-butyl-3-chloro-6-ethoxyquinoxaline-5-carboxylic acid 
• 150368-40-4 2-butyl-6-ethoxy-5-(ethoxycarbonyl)-1,2-dihydroquinoxalin-3(4H)-one 
• 150368-41-5 2-butyl-6-ethoxy-(5-ethoxycarbonyl)quinoxalin-3(4H)-one 
• 150368-42-6 2-butyl-6-ethoxy-5-(hydroxycarbonyl)quinoxalin-3(4H)-one 
• 150368-38-0 ethyl 1-amino-6-ethoxy-3-nitrobenzoate 
• 150368-36-8 ethyl 2,6-difluoro-3-nitrobenzoate 
• 150368-37-9 ethyl 2-amino-6-fluoro-3-nitrobenzoate 
• 150368-39-1 ethyl 2,3-diamino-6-ethoxybenzoate 

Downstream Products

• 150368-49-3 2-methyl-1-(1-oxopropoxy)propyl-2-butyl-6-ethoxy-3-<<2'-1H-tetrazol-5-yl<1,1'-biphenyl>-4-yl>oxy>-5-quinoxalinecarboxylate 

Relevant academic research and scientific papers

Quinoxaline biphenyl angiotensin II inhibitors

Angiotensin II inhibition is exhibited by STR1 wherein: X is --CH2 -- or O; R is hydrogen, alkyl, aryl, cycloalkyl, aralkyl, or cycloalkylalkyl; R1 and R2 are each independently O or absent; R3 is hydrogen, alkyl, alkenyl, alkoxy, cycloalkyl, aryl, aralkyl, cycloalkylalkyl, halo, haloalkyl, or haloalkoxy; R4 is hydrogen, alkyl, alkenyl, alkoxy, aryl, cycloalkyl, aralkyl, cycloalkylalkyl, --R8 --OH, or --R8 CO2 R9 ; and the remaining symbols are as defined in the specification.

Quinoxaline N-oxide containing potent angiotensin II receptor antagonists: Synthesis, biological properties, and structure-activity relationships

A series of novel quinoxaline heterocycle containing angiotensin II receptor antagonist analogs were prepared. This heterocycle was coupled to the biphenyl moiety via an oxygen atom linker instead of a carbon atom. Many of these analogs exhibit very poten