150368-36-8

Upstream product

• 19064-14-3 2,6-Difluorobenzoic acid,ethyl ester 
• 18063-02-0 2,6-difluorobenzoylchloride 
• 446-35-5 2,4-Difluoronitrobenzene 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 269072-20-0 3-amino-2,6-difluoro-benzoic acid ethyl ester 
• 150368-49-3 2-methyl-1-(1-oxopropoxy)propyl-2-butyl-6-ethoxy-3-<<2'-1H-tetrazol-5-yl<1,1'-biphenyl>-4-yl>oxy>-5-quinoxalinecarboxylate 
• 150368-48-2 2-Butyl-6-ethoxy-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]oxy]quinoxaline-5-carboxylic acid 
• 150368-38-0 ethyl 1-amino-6-ethoxy-3-nitrobenzoate 
• 150368-39-1 ethyl 2,3-diamino-6-ethoxybenzoate 
• 150368-37-9 ethyl 2-amino-6-fluoro-3-nitrobenzoate 

Relevant academic research and scientific papers

Quinoxaline N-oxide containing potent angiotensin II receptor antagonists: Synthesis, biological properties, and structure-activity relationships

A series of novel quinoxaline heterocycle containing angiotensin II receptor antagonist analogs were prepared. This heterocycle was coupled to the biphenyl moiety via an oxygen atom linker instead of a carbon atom. Many of these analogs exhibit very poten

Regio-and chemoselective zincation of sensitive and moderately activated aromatics and heteroaromatics using TMPZnCl·LiCl

(Figure Presented) A broad range of functionalized aryl- and heteroarylzinc reagents were prepared via directed zincation of sensitive and moderately activated aromatics and heteroaromatics using TMPZnCl·LiCl under various reaction conditions. Diverse sensitive functional groups such as a nitro group, an aldehyde, an ester, and a nitrile are readily tolerated and are compatible with high metalation temperatures. Furthermore, the resulting zinc organometallics display an excellent reactivity toward various classes of electrophiles providing functionalized aromatics and heteroaromatics in high yields.

Quinoxaline biphenyl angiotensin II inhibitors

Angiotensin II inhibition is exhibited by STR1 wherein: X is --CH2 -- or O; R is hydrogen, alkyl, aryl, cycloalkyl, aralkyl, or cycloalkylalkyl; R1 and R2 are each independently O or absent; R3 is hydrogen, alkyl, alkenyl, alkoxy, cycloalkyl, aryl, aralkyl, cycloalkylalkyl, halo, haloalkyl, or haloalkoxy; R4 is hydrogen, alkyl, alkenyl, alkoxy, aryl, cycloalkyl, aralkyl, cycloalkylalkyl, --R8 --OH, or --R8 CO2 R9 ; and the remaining symbols are as defined in the specification.