15043-03-5

Usage

Uses

Used in Pharmaceutical Synthesis:
2,4(1H,3H)-Pyrimidinedione, 6-ethyl(9CI) is used as an intermediate in the synthesis of various pharmaceuticals for its antiviral and antitumor properties. It plays a crucial role in the development of new drugs targeting viral infections and cancer treatment.
Used in Agrochemical Synthesis:
In the agrochemical industry, 2,4(1H,3H)-Pyrimidinedione, 6-ethyl(9CI) is utilized as a building block in the creation of agrochemicals, contributing to the development of effective pest control agents and crop protection products.
Used in Organic Chemistry Research:
6-ethyluracil is employed as a versatile compound in organic chemistry research, enabling the exploration of novel chemical reactions and the synthesis of complex organic molecules.
Used in Biochemical Research:
2,4(1H,3H)-Pyrimidinedione, 6-ethyl(9CI) is used in biochemical research to study the interactions of pyrimidine-based compounds with biological systems, providing insights into their potential applications in medicine and biology.

InChI:InChI=1/C6H8N2O2/c1-2-4-3-5(9)8-6(10)7-4/h3H,2H2,1H3,(H2,7,8,9,10)

Upstream product

• 53939-83-6 6-ethyl-2,3-dihydro-2-thioxopyrimidin-4(1H)-one 
• 5734-66-7 6-ethylisocytosine 
• 82830-93-1 6-ethyl-2-methoxy-4(3H)-pyrimidinone 
• 4949-44-4 ethyl propanoylacetate 
• 57-13-6 urea 
• 6554-65-0 2,4-dichloro-6-ethylpyrimidine 

Downstream Products

• 147909-83-9 6-Ethyl-1-(2,3,5-tri-O-benzoyl-α-D-arabinofuranosyl)uracil 
• 141602-25-7 4-chloro-6-ethylpyrimidine 
• 856160-67-3 6-ethylpyrimidin-4-amine 
• 102170-34-3 6-ethyl-pyrimidine-2,4,5-triyltriamine 
• 1373331-51-1 1-(7-chloro-5-ethyl-1-phenyl-1H-pyrimido[4,5-e][1,3,4]thiadiazin-3-yl)-2-phenyldiazene 
• 178425-35-9 1-[(2R,4S,5S)-4-Azido-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-ethyl-1H-pyrimidine-2,4-dione 
• 178425-34-8 1-[(2S,4S,5S)-4-Azido-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-ethyl-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

DIHYDROPTERIDINONES I

The present invention relates to dihydropteridinones, their use as modulators of γ-secretase and to pharmaceutical compositions containing said compounds. In particular, the present invention relates to compounds which interfere with γ-secretase and/or it

DIHYDROPTERIDINONES II

The present invention relates to spiroheterocycl-dihydropyhmidines, their use as modulators of γ-secretase and to pharmaceutical compositions containing said compounds. In particular, the present invention relates to compounds which interfere with γ-secretase and/or its substrate and therefore modulate the formation of Αβ peptides.

DIHYDROPTERIDINONES I

The present invention relates to dihydropteridinones, their use as modulators of γ-secretase and to pharmaceutical compositions containing said compounds. In particular, the present invention relates to compounds which interfere with γ-secretase and/or it

DIHYDROPTERIDINONES II

The present invention relates to spiroheterocycl-dihydropyrimidines, their use as modulators of γ-secretase and to pharmaceutical compositions containing said compounds. In particular, the present invention relates to compounds which interfere with γ-secretase and/or its substrate and therefore modulate the formation of Aβ peptides.

Synthesis of modified uracil and cytosine nucleobases using a microwave-assisted method

Modified nucleobases and nucleic acids have found many biological and pharmaceutical applications. Here we report a microwave-directed synthesis of a variety of modified uracil and cytosine nucleobases with high yields under solvent-free conditions. The reaction yields were further improved by addition of Lewis acid. The crystal structures of 5-isopropyl-6-methyluracil and 6-phenyluracil were also determined.

Synthesis of an AZT-HEPT hybrid and homologous AzddU derivatives

3′-Azido-2′,3′-dideoxyuridines 6 and their corresponding α anomers 5 were syrthesizes by condensation of silylated 6-alkyl and 5,6-dialkyl substituted uracils 2 with methyl 3-azido-5-O-tert-butyldiphenylsilyl-2,3-dideoxy-α,β-D-erythro- pentofuranoside (4). Compounds 5 and 6 were treated with tetrabutylammonium fluoride to obtain the deprotected nucleosides 7 and 8, respectively. Acta Chemica Scandinavica 1996.

6-ALKYL AND 5,6-DIALKYL-2-METHOXY-4(3H)-PYRIMIDINONES IN THE TRANSFORMATIONS OF PYRIMIDINES-2 SYNTHESIS AND CONVERSION INTO ALKYLURACILS AND 2-ALKOXY-4(3H)-PYRIMIDINONES

The synthesis of 6-alkyl and 5,6-dialkyl-2-methoxy-4(3H)-pyrimidinones 3 is described.Their versatility to be transformed into 6-alkyl and 5,6-dialkyluracils 4(a-h), 6-alkyl and 5,6-dialkyl-3-methyluracils 7(a,e,f) and 6-alkyl and 5,6-dialkyl-2-alkoxy-4(3H)-pyrimidinones 5(a-i) is also shown.