141602-25-7Relevant articles and documents
Synthesis method of voriconazole impurity B
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Paragraph 0028-0029, (2019/10/23)
The invention relates to a synthesis method of a voriconazole impurity B. The synthesis method of the voriconazole impurity B comprises the steps of firstly, dissolving formamidine acetate and sodiumtert-butoxide in methyl alcohol, conducting stirring und
Preparation of triazoles by organometallic addition to ketones and intermediates therefor
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, (2008/06/13)
A process for the preparation of a compound of the formula: or an acid addition or base salt thereof, wherein R is phenyl optionally substituted by 1 to 3 substituents each independently selected from halo and trifluoromethyl; R1 is C1-C6 alkyl; and “Het” is pyrimidinyl optionally substituted by 1 to 3 substituents each independently selected from C1-C4 alkyl, C1-C4 alkoxy, halo, oxo, benzyl and benzyloxy, comprising reacting a compound of the formula: with a compound of the formula wherein X is chloro, bromo or iodo, the reaction taking place in the presence of zinc; at least one of iodine or a Lewis acid; and an aprotic organic solvent: optionally further reacting the resulting compound with an acid or base to form the corresponding acid addition or base salt thereof.
Aryl group- or aromatic heterocyclic group-substituted aminoquinolone derivatives and anti-HIV agent
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, (2008/06/13)
Disclosed are an aryl group- or heterocyclic group-substituted aminoquinolone compound represented by the formula (Ia), (Ib) or (Ic): STR1 wherein each of the substitutents are defined in the specification, or a salt of the compound, and an AIDS curing agent containing the same as an effective ingredient.