150585-08-3 Usage
Synthetic derivative of estradiol
16-formylestradiol is a synthetically produced compound that is derived from the hormone estradiol, which is a form of estrogen.
Potent inhibitor of aldehyde dehydrogenase
The compound is a strong inhibitor of the enzyme aldehyde dehydrogenase, which is involved in the metabolism of alcohol.
Potential use in treating alcohol addiction
16-formylestradiol has been studied for its potential use in treating alcohol addiction by blocking the metabolism of alcohol and causing unpleasant side effects such as nausea and flushing.
Anti-cancer properties
The compound has shown anti-cancer properties in preclinical studies and may have potential applications in the treatment of hormone-sensitive cancers.
Early stages of research and development
16-formylestradiol is still in the early stages of research and development, and further studies are needed to understand its potential therapeutic uses and safety profile.
Check Digit Verification of cas no
The CAS Registry Mumber 150585-08-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,0,5,8 and 5 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 150585-08:
(8*1)+(7*5)+(6*0)+(5*5)+(4*8)+(3*5)+(2*0)+(1*8)=123
123 % 10 = 3
So 150585-08-3 is a valid CAS Registry Number.
InChI:InChI=1/C19H24O3/c1-19-7-6-15-14-5-3-13(21)8-11(14)2-4-16(15)17(19)9-12(10-20)18(19)22/h3,5,8,10,12,15-18,21-22H,2,4,6-7,9H2,1H3/t12-,15-,16-,17+,18+,19+/m1/s1
150585-08-3Relevant articles and documents
Preparation of 16-formylestradiol and the 16-(α-methylenebutanolide) derivative
Akanni, Olufemi A.,Marple, Brian A.
, p. 234 - 238 (1993)
Route tot he preparation of 16-formylestradiol are described. Estronen was converted to (E)-16-methoxy-methylene estrone via the 16-hydroxymethylene estrone. Reduction of themethoxymethylene estrone with NaBH4 in the presence of CeCl3 gave 16-methoxymethylene estradiol. Deprotection by acid afforded the desired 16-formylestradiol. Attempts to prepare the 16-formylestradiol via the 16-butythio-methylene derivative gave only 16-formylestra-1,3,5(10),16-tetraen-3-ol, and a route through the 16-dimethoxymethyl derivative gave a mixture of the 16-formyltetraen-3-ol and the 16-formlestradiol in low yield. The 16-formylestradiol was subsequently converted tot he α-methylene lactone conjugate, 4-(3,17β-dihydroxyestra-1,3,5(10)trien-16-yl)-2-methylene-4-butanolide by reaction with methyl α-(bromomethyl) acrylate and zinc. (Steroids 58: 234-238, 1993).
