150717-69-4

Usage

Chemical structure

A derivative of butanone and piperidine with a 4-chlorophenyl group, a 4-hydroxy-1-piperidinyl group, and a 4-nitrophenyl group.

Molecular weight

Approximately 399.86 g/mol

Appearance

Likely a solid or oily liquid, depending on the temperature

Solubility

Soluble in organic solvents such as ethanol, methanol, and acetone

Stability

Stable under normal temperature and pressure conditions, but sensitive to heat, light, and moisture

Reactivity

May react with strong acids, strong bases, and nucleophiles

Pharmaceutical industry

As a building block for the synthesis of various organic compounds

Medicinal chemistry

Due to the presence of piperidine and phenyl groups, it may exhibit various pharmacological activities and properties

Safety precautions

Handle with care, as it may be toxic or harmful if inhaled, ingested, or absorbed through the skin. Use appropriate personal protective equipment (PPE) and follow proper disposal procedures.

Further research and development

Of interest for its potential applications in the field of medicinal chemistry, warranting further investigation into its pharmacological properties and possible therapeutic uses.

Upstream product

• 39512-49-7 4-(4-chlorophenyl)-4-hydroxypiperidine 
• 93639-13-5 4-chloro-4'-nitrobutyrophenone 
• 103-84-4 Acetanilid 
• 866578-97-4 methanesulfonic acid 4-(4-nitrophenyl)-4-oxobutyl ester 
• 93639-12-4 cyclopropyl(4-nitrophenyl)methanone 
• 56924-11-9 1-(4-acetylaminophenyl)-4-chloro-1-butanone 
• 57189-90-9 (4-aminophenyl)(cyclopropyl)methanone 

Downstream Products

• 52-86-8 haloperidol 

Relevant academic research and scientific papers

Microwave-accelerated fluorodenitrations and nitrodehalogenations: expeditious routes to labeled PET ligands and fluoropharmaceuticals

Methods for the expeditious fluorination of arenes have been investigated, using readily available fluoride sources. An optimized procedure for microwave-accelerated fluorodenitration has been developed, giving good to excellent yields in less than 10 min, rendering it practical for use in the preparation of F18 labeled ligands for PET imaging. Application of the method in the synthesis of CNS agents is demonstrated, and a practical method for the preparation of substrates is also presented.

Rapid and efficient synthesis of high-purity fluorine-18 labeled haloperidol and spiperone via the nitro precursor in combination with a new HPLC separation method

We have completed a convenient synthesis of fluorine-18 labeled butyrophenone neuroleptics from their nitro precursors. Thus, we have developed an efficient single-columm HPLC system using a C18-bonded vinyl alcohol copolymer gel (octadecyl polymer, ODP) column and strongly alkaline solvent systems for purifying of the 18F-labeled butyrophenone neuroleptics obtained by a single-stp 18F-for-nitro exchange reaction. The method has been applied to the synthesis of two typical butyrophenone neuroleptics ([18F]haloperidol and [18F]spiperone) with high purity in high yield. With information concerning the optimized conditions for the 18F-for-nitro exchange reaction, the synthetic method would be useful for synthesizing various 18F-labeled compounds.