150783-50-9

Usage

Uses

Used in Pharmaceutical Industry:
2,2-DIMETHYL-N-[2-METHYL-3-(TRIFLUOROMETHYL)PHENYL]-PROPIONAMIDE is used as an intermediate compound for the synthesis of Flunixin, an analgesic and anti-inflammatory drug. Its role in the pharmaceutical industry is crucial for the development of effective pain relief and inflammation management medications for animals.
Used in Veterinary Medicine:
In the veterinary medicine field, 2,2-DIMETHYL-N-[2-METHYL-3-(TRIFLUOROMETHYL)PHENYL]-PROPIONAMIDE contributes to the production of Flunixin, which is utilized for managing pain and inflammation in various animal species. This application aids in the treatment of conditions that cause discomfort and swelling in animals, ultimately improving their quality of life and overall health.

InChI:InChI=1/C13H16F3NO/c1-8-9(13(14,15)16)6-5-7-10(8)17-11(18)12(2,3)4/h5-7H,1-4H3,(H,17,18)

Upstream product

• 98-16-8 3-trifluoromethylaniline 
• 3282-30-2 pivaloyl chloride 
• 1939-19-1 N-(3-(trifluoromethyl)phenyl)pivalamide 
• 74-88-4 methyl iodide 

Downstream Products

• 38677-85-9 flunixin 
• 54396-42-8 ethyl 2-(2-methyl-3-trifluoromethylanilino)nicotinate 
• 54396-44-0 2-methyl-3-trifluoromethylaniline 

Relevant academic research and scientific papers

Improved Process for the Preparation of 2-Methyl-3-trifluoromethylaniline: A Versatile Intermediate for Flunixin Synthesis

A detailed new experimental investigation into the synthesis of Flunixin via 2-methyl-3-trifluoromethylaniline is described.The coupling process between 2-methyl-3-trifluoromethylaniline and 2-chloronicotinate was achieved stoichiometrically and in high yield, when ethylene glycol was used as reaction solvent at 160 deg C.

Preparation of substituted anilino-nicotinic acid derivatives

Substituted anilino-nicotinic acid derivatives are readily prepared from the condensation of two intermediates, 2-alkyl-3-perfluoroalkyl-anilines and alkyl 2-chloronicotinates. The 2-alkyl-3-perfluoroalkyl-aniline intermediate can be prepared via a novel three step synthesis. 3-Perfluoroalkyl-anilines are reacted with an amine directing protecting group reagent to protect the amine. The protected amine is then alkylated, and finally, the directing group is removed to form the 2-alkyl-3-perfluoroalkyl-aniline intermediate. The 2-alkyl-3-perfluoroalkyl-aniline intermediate is condensed with the alkyl 2-chloronicotinate to form the anilino-nicotinic acid derivative.