Heterocycles p. 2243 - 2246 (1994)
Update date:2022-08-11
Topics:
Jaouhari, Rabih
Quinn, Philip
A detailed new experimental investigation into the synthesis of Flunixin via 2-methyl-3-trifluoromethylaniline is described.The coupling process between 2-methyl-3-trifluoromethylaniline and 2-chloronicotinate was achieved stoichiometrically and in high yield, when ethylene glycol was used as reaction solvent at 160 deg C.
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(1996)
