150785-92-5

Upstream product

• 100-39-0 benzyl bromide 
• 500131-75-9 (4R)-4-Phenylhexahydropyrido<2,1-c><1,4>oxazin-1-one 
• 158341-07-2 (4R,9aR)-4-Phenylhexahydropyrido<2,1-c><1,4>oxazin-1-one 
• 874368-12-4 (3R,5R)-3-(4-iodobutyl)-2-oxo-5-phenyl-morpholine-4-carboxylic acid tert-butyl ester 
• 874368-19-1 (4R,9aS)-9a-allyl-4-phenylhexahydropyrido[2,1-c][1,4]oxazin-1-one 
• 158221-60-4 (4R,9aR)-9a-Benzyl-4-phenylhexahydropyrido<2,1-c><1,4>oxazin-1-one 

Relevant academic research and scientific papers

An efficient, asymmetric synthesis of pipecolic acid and 2-alkyl pipecolic acids

Both (R)- and (S)-pipecolic acids and their 2-alkyl derivatives have been synthesized via diastereoselective alkylations of (R)-5-phenylmorpholin-2-one 5.

Asymmetric Synthesis. 32. A New Access to Enantiomerically Pure (S)-(-)-Pipecolic Acid and 2- or 6-Alkylated Derivatives

Enantiomerically pure (S)-(-)-pipecolic acid (5) was synthesized in four steps and 47percent overall yield starting from 2-cyano-6-phenyloxazolopiperidine (1).A general strategy is described for preparing 2-alkylated and 6-alkylated pipecolic acid 7a-c and 11a-c using diastereoselective procedures.

Asymmetric Synthesis with Chiral 1,4-Oxazine-2,5-diones: Preparation of Enantiomerically Pure 2-Substituted Pipecolic Acid Derivatives

A new asymmetric synthesis of α-amino acids is presented.This synthesis is based on the chiral 1,4-oxazine-2,5-diones 5 and 14 relying on the α-hydroxy acid 12 as a chiral auxiliary.A base-mediated alkylation of these chiral amino acid building blocks (5,