1508-67-4Relevant academic research and scientific papers
Manganese(IV) complexes derived from polyfunctional dihydrazone: Structural, electrochemical and antimicrobial studies
Sarma,Mahanta,Basumatary,Medhi
, p. 1144 - 1152 (2021/05/10)
Manganese(IV) complexes viz. [MnIV(nagh)(A)2]·2H2O and [MnIV(nagh)(NN)] have been synthesized from ligand bis(2-hydroxy-1-naphthaldehyde)glutaryldihydrazone (naghH4) and auxiliary ligands, A = H2O (1)/pyridine (2)/2-picoline (3)/3-picoline (4)/ 4-picoline (5) or NN = 2,2′-bipyridine (6)/1,10-phenanthroline (7). The elemental analysis, mass spectral and thermal studies supported the composition of all the manganese(IV) complexes. Structural aspects were determined from magnetic susceptibility, molar conductivity and spectral studies i.e. electronic, electron spin resonance and infrared. Their non-electrolytic nature were determined from molar conductances. Results from studies of magnetic moment, electronic and ESR suggested Mn(IV) ion in six-coordinate octahedral stereochemistry. The ligand coordinated to the metal in enolic form as a tetradentate in an anti-cis configuration as was correlated from IR data. Redox activities and antimicrobial potential against few Gram-positive and Gram-negative bacteria have been investigated for the dihydrazone and some manganese(IV) complexes.
A toolbox for controlling the properties and functionalisation of hydrazone-based supramolecular hydrogels
Poolman, Jos M.,Maity, Chandan,Boekhoven, Job,Van Der Mee, Lars,Le Sage, Vincent A.A.,Groenewold, G.J. Mirjam,Van Kasteren, Sander I.,Versluis, Frank,Van Esch, Jan H.,Eelkema, Rienk
supporting information, p. 852 - 858 (2016/02/05)
In recent years, we have developed a low molecular weight hydrogelator system that is formed in situ under ambient conditions through catalysed hydrazone formation between two individually non-gelating components. In this contribution, we describe a molecular toolbox based on this system which allows us to (1) investigate the limits of gel formation and fine-tuning of their bulk properties, (2) introduce multicolour fluorescent probes in an easy fashion to enable high-resolution imaging, and (3) chemically modify the supramolecular gel fibres through click and non-covalent chemistry, to expand the functionality of the resultant materials. In this paper we show preliminary applications of this toolbox, enabling covalent and non-covalent functionalisation of the gel network with proteins and multicolour imaging of hydrogel networks with embedded mammalian cells and their substructures. Overall, the results show that the toolbox allows for on demand gel network visualisation and functionalisation, enabling a wealth of applications in the areas of chemical biology and smart materials.
DICARBOXYLIC ACID BISAMIDE DERIVATIVES, USE THEREOF, PHARMACEUTICAL COMPOSITION BASED THEREON AND METHODS FOR PRODUCING DICARBOXYLIC ACID BISAMIDE DERIVATIVES
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Paragraph 0144, (2016/02/21)
The present invention relates to novel biologically active compounds, in particular dicarboxylic acid bisamide derivatives of general formula I: or pharmaceutically acceptable salts thereof, which are able to form complexes with or chelate metal ions. The invention also relates to the use of said compounds as an agent for the prevention and/or treatment of cardiovascular, viral, cancer, neurodegenerative and inflammatory diseases, diabetes, age-related diseases, diseases caused by microbial toxins, alcoholism and alcoholic cirrhosis, anaemia, porphyria cutanea tarda, and transition metal salt poisoning. The present invention also relates to novel methods for preparing dicarboxylic acid bisamide derivatives of general formula I.
Design and synthesis of phenolic hydrazide hydrazones as potent poly(ADP-ribose) glycohydrolase (PARG) inhibitors
Islam, Rafiqul,Koizumi, Fumiaki,Kodera, Yasuo,Inoue, Kengo,Okawara, Tadashi,Masutani, Mitsuko
, p. 3802 - 3806 (2014/09/16)
Poly(ADP-ribose) polymerase (PARP) and poly(ADP-ribose) glycohydrolase (PARG) are enzymes responsible for catalyzing the formation and degradation of poly(ADP-ribose) (PAR) polymers, respectively. Activation of PARP has been shown to be involved in cell death induced by genotoxic stimuli. On the other hand, genetic disruption of PARG also leads to increased level of cell death by accumulation of PAR. Unlike PARP, where significant medicinal effort has been expended to identify potent inhibitors, PARG has been insufficiently investigated as a molecular therapeutic target. In this study, we report the design, synthesis, and biological evaluation of phenolic hydrazide hydrazones as potent PARG inhibitors. Compounds 3d, 3e, 5d, 5e, 8a, 8b and 8c showed their ability to inhibit the catalytic activity of PARG in vitro with IC50 values of 1.0, 2.1, 3.1, 3.2, 3.1, 2.8 and 1.6 μM, respectively.
Enzymatic hydrazinolysis of diesters and synthesis of N-aminosuccinimide derivatives
Astorga,Rebolledo,Gotor
, p. 287 - 289 (2007/10/02)
Selective hydrazinolysis of diesters is catalyzed by PS lipase. This enzyme is an efficient catalyst for the preparation of N-aminosuccinimide derivatives.
Synthesis and Characterization of Nitrato and Acetato Complexes of Dioxouranium(VI) with Disalicylaldehyde Acyl Hydrazones
Das, S.,Lal, R. A.
, p. 225 - 230 (2007/10/02)
Dioxouranium(VI) complexes of disalicylaldehyde oxaloyldihydrazone (H4A2), malonoyldihydrazone (H4B2), succinoyldihydrazone (H4C2), glutaroyldihydrazone (H4D2), adipoyldihydrazone (H4E2) and phthaloyldihydrazone (H4F2) have been synthesized from the reaction of uranyl nitrate hexahydrate and uranyl acetate dihydrate with the title ligands in alcoholic medium.The complexes have the compositions .2H2O and .C2H5OH where H4L2 = H4A2, H4B2, H4C2, H4D2, H4E2 and H4F2.The complexes have been characterized on the basis of elemental analyses, TGA, DTA, molar conductance, infrared and Raman spectral data.
