1508-67-4

Basic information

• Product Name: GLUTARIC DIHYDRAZIDE
• Synonyms: AKOS BBS-00001038;GLUTARIC DIHYDRAZIDE;pentanedihydrazide;pentanedioic acid, dihydrazide;glutarohydrazide
• CAS NO: 1508-67-4
• Molecular Formula: C₅H₁₂N₄O₂
• Molecular Weight: 160.17
• Mol File: 1508-67-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 529.1°Cat760mmHg
• Flash Point: 273.8°C
• Appearance: /
• Density: 1.229g/cm³
• Vapor Pressure: 2.8E-11mmHg at 25°C
• Refractive Index: 1.518
• CAS DataBase Reference: GLUTARIC DIHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: GLUTARIC DIHYDRAZIDE(1508-67-4)
• EPA Substance Registry System: GLUTARIC DIHYDRAZIDE(1508-67-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1508-67-4(Hazardous Substances Data)

Usage

General Description

Glutaric dihydrazide (GDH) is a chemical compound with the formula C5H10N4O2. It is a white crystalline powder that is primarily used as a cross-linking agent in the production of thermosetting resins, particularly in the manufacture of polyurethane adhesives and coatings. GDH's ability to form cross-links within the polymer matrix improves the mechanical, thermal, and chemical properties of the final product. It is also utilized in the production of pesticides, pharmaceuticals, and as a photographic developer. Additionally, glutaric dihydrazide is a popular de-icing compound for use on aircraft and runways due to its ability to inhibit the formation of ice. However, it should be handled with caution as it is a skin and eye irritant, and prolonged exposure may cause adverse health effects.

InChI:InChI=1/C5H12N4O2/c6-8-4(10)2-1-3-5(11)9-7/h1-3,6-7H2,(H,8,10)(H,9,11)

Upstream product

• 818-38-2 Diethyl glutarate 
• 110-94-1 1,5-pentanedioic acid 
• 1119-40-0 Dimethyl glutarate 

Downstream Products

• 132500-94-8 C₁₉H₂₀N₄O₄ 
• 112008-82-9 disalicylaldehyde glutaroyldihydrazone 
• 81421-05-8 CoHOC₆H₄CHNNHCO(CH₂)3CONHNCHC₆H₄OI 
• 1622386-26-8 C₁₉H₂₀N₄O₈ 

Relevant articles and documents

Manganese(IV) complexes derived from polyfunctional dihydrazone: Structural, electrochemical and antimicrobial studies

Manganese(IV) complexes viz. [MnIV(nagh)(A)2]·2H2O and [MnIV(nagh)(NN)] have been synthesized from ligand bis(2-hydroxy-1-naphthaldehyde)glutaryldihydrazone (naghH4) and auxiliary ligands, A = H2O (1)/pyridine (2)/2-picoline (3)/3-picoline (4)/ 4-picoline (5) or NN = 2,2′-bipyridine (6)/1,10-phenanthroline (7). The elemental analysis, mass spectral and thermal studies supported the composition of all the manganese(IV) complexes. Structural aspects were determined from magnetic susceptibility, molar conductivity and spectral studies i.e. electronic, electron spin resonance and infrared. Their non-electrolytic nature were determined from molar conductances. Results from studies of magnetic moment, electronic and ESR suggested Mn(IV) ion in six-coordinate octahedral stereochemistry. The ligand coordinated to the metal in enolic form as a tetradentate in an anti-cis configuration as was correlated from IR data. Redox activities and antimicrobial potential against few Gram-positive and Gram-negative bacteria have been investigated for the dihydrazone and some manganese(IV) complexes.

DICARBOXYLIC ACID BISAMIDE DERIVATIVES, USE THEREOF, PHARMACEUTICAL COMPOSITION BASED THEREON AND METHODS FOR PRODUCING DICARBOXYLIC ACID BISAMIDE DERIVATIVES

The present invention relates to novel biologically active compounds, in particular dicarboxylic acid bisamide derivatives of general formula I: or pharmaceutically acceptable salts thereof, which are able to form complexes with or chelate metal ions. The invention also relates to the use of said compounds as an agent for the prevention and/or treatment of cardiovascular, viral, cancer, neurodegenerative and inflammatory diseases, diabetes, age-related diseases, diseases caused by microbial toxins, alcoholism and alcoholic cirrhosis, anaemia, porphyria cutanea tarda, and transition metal salt poisoning. The present invention also relates to novel methods for preparing dicarboxylic acid bisamide derivatives of general formula I.

Enzymatic hydrazinolysis of diesters and synthesis of N-aminosuccinimide derivatives

Selective hydrazinolysis of diesters is catalyzed by PS lipase. This enzyme is an efficient catalyst for the preparation of N-aminosuccinimide derivatives.