150807-96-8

Usage

Uses

Used in Pharmaceutical Industry:
4-CHLORO-6-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE is used as a building block for the synthesis of biologically active compounds, contributing to the development of new pharmaceuticals due to its unique structural features that can be incorporated into drug molecules.
Used in Agrochemical Industry:
In the agrochemical sector, 4-CHLORO-6-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE is used as an intermediate in the production of herbicides and fungicides. Its role in these applications is crucial for enhancing crop protection and yield.
Used in Chemical Synthesis:
4-CHLORO-6-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE is also utilized in the synthesis of dyes and pigments, playing a significant role in the creation of specialty chemicals that have various applications in different industries.

Upstream product

• 17823-58-4 ethyl 2-cyano-3,3-di(methylsulfanyl)acrylate 
• 3490-92-4 methyl 2-cyano-3,3-bis(methylsulfanyl)acrylate 
• 16071-28-6 3,4-dihydro-6-methymercapto-4-oxopyrimidine-5-carbonitrile 

Downstream Products

• 868272-34-8 3-(5-cyano-6-(methylthio)pyrimidin-4-ylamino)-N-methoxy-4-methylbenzoic acid 
• 868272-28-0 3-(5-cyano-6-(methylthio)pyrimidin-4-ylamino)-N-methoxy-4-methylbenzamide 
• 868272-36-0 3-(5-cyano-6-(methylthio)pyrimidin-4-ylamino)-N-(1-ethyl-1H-pyrazol-5-yl)-4-methylbenzamide 
• 868272-35-9 3-(5-cyano-6-(methylthio)pyrimidin-4-ylamino)-N-(isoxazol-3-yl)-4-methylbenzamide 
• 868272-29-1 3-(5-cyano-6-(methylsulfonyl)pyrimidin-4-ylamino)-N-methoxy-4-methylbenzamide 

Relevant academic research and scientific papers

5-Cyanopyrimidine derivatives as a novel class of potent, selective, and orally active inhibitors of p38a MAP kinase

A novel class of 5-cyanopyrimidine-based inhibitors of p38a MAP kinase has been investigated. Analogues optimized through SAR iterations display low nanomolar enzymatic and cellular activity. The in vivo efficacy of this class of p38 inhibitors was demonstrated by 3a and 3b (>50% reduction in TNF levels when orally dosed at 5 mg/kg, 5 h prior to LPS administration in an acute murine model of inflammation). For 3a and 3b, the previously identified N-methoxybenzamide moiety (1) was replaced with N-(isoxazol-3-yl)benzamide, thereby providing increased metabolic stability. Cyanopyrimidine 3a demonstrated 100% oral bioavailability in mouse. High p38 kinase selectivity versus over 20 kinases was observed for analogue 3b. Direct hydrogen bonding of the cyano nitrogen of the 5-cyanopyrimidine core to the backbone NH of Met109 was confirmed by X-ray crystallographic analysis of 3a bound to p38α.

Suitably functionalised pyrimidines as potential antimycotic agents

Various suitably functionalised pyrimidine derivatives have been synthesized to explore their potential as antimycotic agents. Some of the synthesized compounds 4c, 4d, 8a-e have shown highly significant in vitro antifungal activity against five human pathogenic fungi. (C) 2000 Elsevier Science Ltd. All rights reserved.

Chemotherapeutic agents: Part XXIII - Synthesis of π-deficient pyrimidines and fused pyrimidines as leishmanicides

Various ?-deficient pyrimidines and fused purimidines have been synthesized and evaluated for their leishmanicidal activity against L. donovani.