150807-99-1Relevant articles and documents
Chloropyrimidines as a new class of antimicrobial agents
Agarwal, Nidhi,Srivastava, Pratibha,Raghuwanshi, Sandeep K,Upadhyay,Sinha, Sudhir,Shukla,Ji Ram, Vishnu
, p. 869 - 874 (2002)
In the course of our investigations of pyrimidines as antimycotic agents, we have idenified a sub-class, with significant in vitro activity agains mycobacteria. The salient feature of these pyrimidine derivatives (3a o and 7a,b) is their appended aryl, heteroaryl and alkylthio subst ituent a position 6 and also alkylthio substituent at position 2. The rational design, synthesis, and evaluation of the in vitro antibacterial activity against six pathogenic bacteria including virulent and non-virulent strains of M cobacterium tuberculosis is described. Some of the synthesized compounds (3c, 3h, 3i, 3o) have displayed only potent in vitro antimycobacterial activity with MIC of 0.75 μ/mL excep 3i which also demonstrated activity against Escherichia coli a 12.5 μg/mL concentration. Only two compounds, 3a and 3b, demonstrated antibacterial activity agains Pseudomonas aeruginosa and E. coli with MIC 12.5 μg/mL. All the synthesized compounds were also evaluated for their antimycotic activity agains five pathogenic fungi but only some of them 3j n and 7a,b were found most potent against Aspergillus fumigatus and Trichophyton mentagrophytes. Copyright
Suitably functionalised pyrimidines as potential antimycotic agents
Agarwal, Nidhi,Raghuwanshi, Sandeep K.,Upadhyay,Shukla,Ram, Vishnu J.
, p. 703 - 706 (2007/10/03)
Various suitably functionalised pyrimidine derivatives have been synthesized to explore their potential as antimycotic agents. Some of the synthesized compounds 4c, 4d, 8a-e have shown highly significant in vitro antifungal activity against five human pathogenic fungi. (C) 2000 Elsevier Science Ltd. All rights reserved.
