150884-13-2

Basic information

• Product Name: O⁴-Allyl-3'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)thymidine
• Synonyms: O⁴-Allyl-3'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)thymidine
• CAS NO: 150884-13-2
• Molecular Weight: 698.932
• Mol File: 150884-13-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: O⁴-Allyl-3'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)thymidine(CAS DataBase Reference)
• NIST Chemistry Reference: O⁴-Allyl-3'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)thymidine(150884-13-2)
• EPA Substance Registry System: O⁴-Allyl-3'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)thymidine(150884-13-2)

Safety Data

• Hazardous Substances Data: 150884-13-2(Hazardous Substances Data)

Upstream product

• 107-18-6 allyl alcohol 
• 80971-33-1 5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxythymidine 

Downstream Products

• 150884-11-0 N⁽³⁾-Allyl-3'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)thymidine 
• 150884-15-4 O⁴-Allyl-5'-O-(p,p'-dimethoxytrityl)thymidine 
• 80971-33-1 5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxythymidine 

Relevant articles and documents

Synthesis and Evaluation of Neutral Phosphate Triester Backbone-Modified siRNAs

Two unsymmetrical dinucleotide phosphate triesters were synthesized via transesterification from tris(2,2,2-trifluoroethyl) phosphate. The protected triesters were phosphytilated to generate phosphoramidites for solid-phase oligonucleotide synthesis. Neutral phenylethyl phosphate-modified short-interfering RNAs (siRNAs) were synthesized and evaluated for their gene-silencing ability, siRNA strand selection, and resistance to nucleases. These backbone-modified phosphate triester siRNAs offer many improvements compared to natural unmodified siRNAs.