ACS Medicinal Chemistry Letters p. 1457 - 1462 (2020)
Update date:2022-08-06
Topics:
Desaulniers, Jean-Paul
Hammill, Matthew L.
Kitamura, Mitsuru
Okauchi, Tatsuo
Tsubaki, Kouta
Varley, Andrew J.
Two unsymmetrical dinucleotide phosphate triesters were synthesized via transesterification from tris(2,2,2-trifluoroethyl) phosphate. The protected triesters were phosphytilated to generate phosphoramidites for solid-phase oligonucleotide synthesis. Neutral phenylethyl phosphate-modified short-interfering RNAs (siRNAs) were synthesized and evaluated for their gene-silencing ability, siRNA strand selection, and resistance to nucleases. These backbone-modified phosphate triester siRNAs offer many improvements compared to natural unmodified siRNAs.
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Doi:10.1021/ja411096m
(2014)Doi:10.1021/ol402865t
(2014)Doi:10.1016/S0040-4020(01)80424-5
(1993)Doi:10.1134/S1070428013110067
(2013)Doi:10.1038/nature24632
(2017)Doi:10.1021/je901091f
(2010)
