173422-30-5

Basic information

• Product Name: (1S,2S,3R,4S,5R,7S,8R,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-9-oxo-1,10,13-trihydroxytax-11-ene
• Synonyms: (1S,2S,3R,4S,5R,7S,8R,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-9-oxo-1,10,13-trihydroxytax-11-ene
• CAS NO: 173422-30-5
• Molecular Weight: 528.599
• Mol File: 173422-30-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 676.9±55.0 °C(Predicted)
• Density: 1.36±0.1 g/cm3(Predicted)
• CAS DataBase Reference: (1S,2S,3R,4S,5R,7S,8R,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-9-oxo-1,10,13-trihydroxytax-11-ene(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S,3R,4S,5R,7S,8R,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-9-oxo-1,10,13-trihydroxytax-11-ene(173422-30-5)
• EPA Substance Registry System: (1S,2S,3R,4S,5R,7S,8R,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-9-oxo-1,10,13-trihydroxytax-11-ene(173422-30-5)

Safety Data

• Hazardous Substances Data: 173422-30-5(Hazardous Substances Data)

Usage

Description

(1S,2S,3R,4S,5R,7S,8R,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-9-oxo-1,10,13-trihydroxytax-11-ene is a complex taxane diterpene molecule characterized by its unique stereochemistry and multiple oxygenated functional groups. It features acetoxy, benzoyloxy, and hydroxy groups, along with an epoxy ring and a ketone group, all anchored to a taxane backbone. (1S,2S,3R,4S,5R,7S,8R,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-9-oxo-1,10,13-trihydroxytax-11-ene is of significant interest due to its potential medicinal properties, particularly in the field of cancer treatment, as it belongs to the taxol-like compounds that have been developed into important chemotherapy drugs.

Uses

Used in Pharmaceutical Industry:
(1S,2S,3R,4S,5R,7S,8R,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-9-oxo-1,10,13-trihydroxytax-11-ene is used as a potential chemotherapeutic agent for the treatment of cancer. Its taxane backbone and functional groups contribute to its medicinal properties, making it a candidate for further research and development in oncology. Taxanes are known for their ability to stabilize microtubules, disrupt cell division, and induce apoptosis in cancer cells, which is why this compound holds promise in the development of new cancer therapies.

Upstream product

• 170575-25-4 7-OTf-10DAB 
• 478161-64-7 (1S,2S,3R,4S,5R,7S,8S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-10-formyloxy-1,13-dihydroxy-9-oxo-7-trifluoromethanesulfonyloxytax-11-ene 
• 32981-86-5 10-deacetylbaccatin III 
• 272129-02-9 (1S,2S,3R,4S,5R,7S,8R,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-9-oxo-1,10,13-trihydroxytax-6,11-diene 
• 184586-80-9 C₃₀H₃₆O₁₀ 
• 150930-83-9 7-deshydroxy baccatine III 
• 184586-79-6 C₃₄H₃₈N₂O₁₁S 
• 184586-78-5 (1S,2S,3R,4S,5R,7S,8S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-10-formyloxy-9-oxo-1,7,13-trihydroxytax-11-ene 

Downstream Products

• 173422-31-6 C₃₁H₃₈O₉S₂ 
• 184586-81-0 (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-(acetoxy)-2-(benzoyloxy)-5,20-epoxy-1,9,10,13-tetrahydroxytax-11-ene 
• 184586-13-8 C₃₂H₄₂O₉ 
• 333327-25-6 C₃₂H₄₀O₈ 
• 333754-43-1 (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-9,10-[(1S)-2-(dimethylamino)ethylidenedioxy]-5,20-epoxy-1-hydroxytax-11-en-13-yl (2R,3S)-3-(tert-butoxycarbonylamino)-3-(3-fluoro-2-pyridyl)-2-triisopropylsilyloxypropionate 
• 1353548-60-3 C₃₃H₄₅NO₉ 
• 184586-82-1 C₃₂H₄₀O₉ 

Relevant articles and documents

Taxane Compounds, Compositions And Methods

The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.

A new method for synthesis of 7-deoxytaxane analogues by hydrogenation of Δ6,7-taxane derivatives

A new method for the synthesis of 7-deoxytaxane analogues has been established through hydrogenation of Δ6,7-taxane derivatives. Among several catalysts examined, Pd-C was found to be a most effective catalyst for the preparation of target compound.