150932-49-3Relevant academic research and scientific papers
Asymmetric Conjugate Additions of Chiral Allyl- and Crotylphosphonamide Anions to α,β-Unsaturated Carbonyl Compounds: Highly Stereocontrolled Access to Vicinally Substituted Carbon Centers and Chemically Asymmetrized Chirons
Hanessian, Stephen,Gomtsyan, Arthur,Payne, Andrew,Herve, Yolande,Beaudoin, Serge
, p. 5032 - 5034 (1993)
Reactions of anions derived from chiral nonracemic allyl and crotyl bicyclic phosphonamides with α,β-unsaturated cyclic ketones, esters, lactones, and lactams take place at the γ-position of the reagents and lead to diastereomerically pure or highly enric
Asymmetric conjugate additions of chiral phosphonamide anions to α,β-unsaturated carbonyl compounds. A versatile method for vicinally substituted chirons
Hanessian, Stephen,Gomtsyan, Arthur,Malek, Nadia
, p. 5623 - 5631 (2007/10/03)
Reactions of anions derived from chiral nonracemic allyl, crotyl, and cinnamyl bicyclic C2-symmetrical phosphonamides with α,β-unsaturated cyclic ketones, esters, lactones, and lactams take place at the γ-position of the reagents. The products are diastereomerically pure or enriched β-substituted carbonyl compounds. The method also provides easy access to vicinal substitution of as many as three stereogenic centers including in some cases quaternary carbon atoms, in a one-pot sequence.
