150932-97-1Relevant academic research and scientific papers
2-Aryl-N-acyl indole derivatives as liver X receptor (LXR) agonists
Kher, Sunil,Lake, Kirk,Sircar, Ila,Pannala, Madhavi,Bakir, Farid,Zapf, James,Xu, Kui,Zhang, Shao-Hui,Liu, Juping,Morera, Lisa,Sakurai, Naoki,Jack, Rick,Cheng, Jie-Fei
, p. 4442 - 4446 (2008/02/11)
Structure-activity relationship studies on a series of Boc-indole derivatives as LXR agonists are described. Compound 1 was identified as an LXR agonist through structure-based virtual screening followed by high-throughput gene profiling. Replacement of t
Synthesis and properties of a novel family of fluorous triphenylphosphine derivatives
Richter,De Wolf,Van Koten,Deelman
, p. 3885 - 3893 (2007/10/03)
A novel approach to the preparation of perfluorotail-functionalized triarylphosphines using a p-silyl substituent as the branching point has been developed. This approach enabled the attachment of between three and nine perfluorotails per phosphorus atom, resulting in the production of highly fluorous tris[p-(1H,1H,2H,2H-perfluoroalkylsilyl)aryl]phosphines, P[C6H4-p-SiMe3-n(CH2 CH2CxF2x+1)n]3 (n = 1, 2, 3; x = 6, 8), containing between 50 and 67 wt % fluorine. 31P NMR studies indicate that the phosphorus atoms, and consequently the σ-donor and π-acceptor properties of these phosphines, are not influenced by the electron-withdrawing perfluoroalkyltails. The fluorous triarylphosphines are readily soluble in fluorous solvents and display fluorous phase preference in several fluorous biphasic systems. The phase partitioning of these fluorous ligands, as well as their donor properties, is discussed in relation to their potential for fluorous biphasic catalyst separation.
