150988-47-9

Upstream product

• 135663-75-1 ((E)-3-Iodo-but-2-ene-1-sulfonyl)-benzene 

Downstream Products

• 150988-48-0 (E)-(2R,5S)-10-Benzenesulfonyl-5-hydroxy-2,8-dimethyl-7-oxo-dec-8-enoic acid ethyl ester 
• 150988-50-4 (3R,6S)-6-((E)-(S)-5-Benzenesulfonyl-2-hydroxy-3-methyl-pent-3-enyl)-3-methyl-tetrahydro-pyran-2-one 
• 150988-51-5 (3R,6S)-6-((E)-(S)-5-Benzenesulfonyl-2-methoxy-3-methyl-pent-3-enyl)-3-methyl-tetrahydro-pyran-2-one 
• 150988-49-1 (E)-(2R,5S,7S)-10-Benzenesulfonyl-5,7-dihydroxy-2,8-dimethyl-dec-8-enoic acid ethyl ester 
• 150988-52-6 (E)-(2R,5S,7S)-10-Benzenesulfonyl-5-hydroxy-7-methoxy-2,8-dimethyl-dec-8-enoic acid methyl ester 
• 150988-53-7 (E)-(2R,5S,7S)-10-Benzenesulfonyl-5-(tert-butyl-dimethyl-silanyloxy)-7-methoxy-2,8-dimethyl-dec-8-enoic acid methyl ester 
• 150988-54-8 [(E)-(4S,6S,9R)-6-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-3,9-dimethyl-10-triethylsilanyloxy-dec-2-ene-1-sulfonyl]-benzene 

Relevant academic research and scientific papers

An application of the evans-prasad 1,3-syn diol synthesis to a stereospecific synthesis of the C10-C27 segment of rapamycin

An efficient regioselective and stereoselective approach to the C10-C27 fragment of rapamycin is described.