1509943-41-2Relevant articles and documents
Synthesis and antiproliferative properties of novel naringenin derivatives
Liu, Su-You,Zeng, Jiang,Peng, Kun-Jian,Zhang, Li-Chao,Liu, Li-Jun,Luo, Zhi-Yong,Ma, Da-You
, p. 2692 - 2698 (2017)
In order to improve the antiproliferative activity of naringenin, a naturally occurred flavonoid in citrus fruits, a series of naringenin derivatives with a tertiary amino side chain were prepared. The antiproliferative activities of these naringenin derivatives were evaluated on four human cancer cell lines, namely, MCF-7, HCT116, Hela, and A549. Compounds 4a, 9a, and 10a exhibited remarkably enhanced growth inhibition activity. Based on the observed results, the structure–activity relationship of these derivatives was discussed.