151011-85-7Relevant articles and documents
Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease
Shie, Jiun-Jie,Fang, Jim-Min,Kuo, Chih-Jung,Kuo, Tun-Hsun,Liang, Po-Huang,Huang, Hung-Jyun,Yang, Wen-Bin,Lin, Chun-Hung,Chen, Jiun-Ling,Wu, Yin-Ta,Wong, Chi-Huey
, p. 4469 - 4473 (2007/10/03)
A diversified library of peptide anilides was prepared, and their inhibition activities against the SARS-CoV 3CL protease were examined by a fluorogenic tetradecapeptide substrate. The most potent inhibitor is an anilide derived from 2-chloro-4-nitroanili
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics
Dragovich, Peter S.,Prins, Thomas J.,Zhou, Ru,Fuhrman, Shella A.,Patick, Amy K.,Matthews, David A.,Ford, Clifford E.,Meador III, James W.,Ferre, Rose Ann,Worland, Stephen T.
, p. 1203 - 1212 (2007/10/03)
The structure-based design, chemical synthesis, and biological evaluation of various ketomethylene-containing human rhinovirus (HRV) 3C protease (3CP) inhibitors are described. These compounds are comprised of a peptidomimetic binding determinant and an e