61229-07-0Relevant academic research and scientific papers
Synthetic method and application of Euproctis pseudoconspersa Strand pheromone
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Paragraph 0033; 0034; 0035; 0036, (2017/08/31)
The invention relates to the field of pesticide chemical technology, specifically to a synthetic method of Euproctis pseudoconspersa Strand pheromone. The Euproctis pseudoconspersa Strand pheromone is (R)-10,14-dimethylpentadecaneisobutyrate, which is syn
Enantioselective bromolactonization of cis-1,2-disubstituted olefinic acids using an amino-thiocarbamate catalyst
Tan, Chong Kiat,Le, Chencheng,Yeung, Ying-Yeung
supporting information; experimental part, p. 5793 - 5795 (2012/08/08)
A facile, highly regio- and enantioselective amino-thiocarbamate-catalyzed bromolactonization of cis-1,2-disubstituted olefinic acids has been developed. The use of the enantio-enriched lactones in the synthesis of chiral synthetic intermediates is also demonstrated. 2012
Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
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, (2008/06/13)
Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compos
Antipicornaviral compounds compositions containing them and methods for their use
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, (2008/06/13)
Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treatin
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics
Dragovich, Peter S.,Prins, Thomas J.,Zhou, Ru,Fuhrman, Shella A.,Patick, Amy K.,Matthews, David A.,Ford, Clifford E.,Meador III, James W.,Ferre, Rose Ann,Worland, Stephen T.
, p. 1203 - 1212 (2007/10/03)
The structure-based design, chemical synthesis, and biological evaluation of various ketomethylene-containing human rhinovirus (HRV) 3C protease (3CP) inhibitors are described. These compounds are comprised of a peptidomimetic binding determinant and an e
A general and stereoselective synthesis of the capsaicinoids via the orthoester Claisen rearrangement
Kaga, Harumi,Goto, Kouhei,Takahashi, Tomiki,Hino, Masao,Tokuhashi, Takashi,Orito, Kazuhiko
, p. 8451 - 8470 (2007/10/03)
Capsaicin, a main pungent principle of hot pepper, and its 15 analogs have been efficiently synthesized. The key step of this synthetic scheme is the orthoester Claisen rearrangement, which transformed allylic alcohols 2A-C to (E)-alkenoates 3A-C (E/Z > 100) in a highly stereoselective manner. The subsequent carbon chain elongations on 3 based on the cyanation or the malonic acid ester synthesis afforded (E)-alkenoic acids 8, which were converted to the corresponding acid chloride and then coupled with vanillylamine to give capsaicinoids. HPLC and CE (capillary electrophoresis) analyses of these capsaicinoids were also carried out.
Biosynthesis of tetronasin: Part 6. Preparation of structural analogues of the diketide and triketide biosynthetic precursors to tetronasin
Less, Simon L.,Handa, Sandeep,Millburn, Karen,Leadlay, Peter F.,Dutton, Christopher J.,Staunton, James
, p. 3515 - 3518 (2007/10/03)
The preparation of three analogues of the putative diketide biosynthetic precursor (2) and eight analogues of the putative triketide biosynthetic precursor (3) of the acyl tetronic acid ionophore tetronasin, as N-acetylcysteamine thioesters (4), (5), (6), (12), (13), (14), (15), (22), (23), (24) and (25) is described. Five examples are 19F-labelled; a new, enantiospecific method for the creation of a fluorinated quarternary α-centre is presented.
An Alternate Synthesis of the Capsaicinoids
Kaga, Harumi,Goto, Kouhei,Fukuda, Takashi,Orito, Kazuhiko
, p. 946 - 948 (2007/10/02)
Five capsaicinoids, the pungent ingredients of hot peppers, have been efficiently synthesized by a method involving the Wittig reaction between isobutyl triphenylphosphorane and the appropriate lactols (3), followed by the nitrous acid-induced isomerization of the resultant (Z)-olefins (4) to (E)-olefins (5).
The Capsaicinoids: Their Separation, Synthesis, and Mutagenicity
Gannett, Peter M.,Nagel, Donald L.,Reilly, Pam J.,Lawson, Terence,Sharpe, Jody,Toth, Bela
, p. 1064 - 1071 (2007/10/02)
Capsaicin (1b), the pungent ingredient in many varietes of Capsicums has recently been implicated as a possible carcinogen.When obtained from natural sources 1b is always accompanied by a number of related homologues.We have isolated seven of these homologues, characterized them, and synthesized them by a general and unique route developed in our laboratories.Also reported are mutagenicity data for 1b and an extract of red pepper as measured by the Ames assay and the V-79 mammalian cell assay.
