151070-80-3 Usage
Uses
Used in Pharmaceutical Industry:
Methimepip is used as a pharmaceutical agent for its histamine H3 receptor agonist properties. It is particularly valuable in the development of drugs targeting the histamine H3 receptor, which is involved in various physiological processes, including wakefulness, appetite regulation, and cognitive function. Methimepip's agonist activity can be utilized to modulate these processes and potentially treat conditions related to them.
Used in Research Applications:
In the field of scientific research, Methimepip is used as a research tool to study the histamine H3 receptor's role in various biological processes. Its selective agonist activity allows researchers to investigate the receptor's function and its potential as a therapeutic target for various diseases and disorders.
Used in Drug Development:
Methimepip is also used in the development of new drugs targeting the histamine H3 receptor. Its agonist properties make it a valuable compound for designing and testing novel therapeutic agents that can potentially treat a range of conditions, including sleep disorders, cognitive impairments, and metabolic diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 151070-80-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,1,0,7 and 0 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 151070-80:
(8*1)+(7*5)+(6*1)+(5*0)+(4*7)+(3*0)+(2*8)+(1*0)=93
93 % 10 = 3
So 151070-80-3 is a valid CAS Registry Number.
151070-80-3Relevant academic research and scientific papers
Kitbunnadaj, Ruengwit,Hashimoto, Takeshi,Poli, Enzo,Zuiderveld, Obbe P.,Menozzi, Alessandro,Hidaka, Ryoko,De Esch, Iwan J. P.,Bakker, Remko A.,Menge, Wiro M. P. B.,Yamatodani, Atsushi,Coruzzi, Gabriella,Timmerman, Henk,Leurs, Rob
, p. 2100 - 2107 (2005)
In this study, we continue our efforts toward the development of potent and highly selective histamine H3 receptor agonists. We introduced various alkyl or aryl alkyl groups on the piperidine nitrogen of the known H3/H4 agonist immepip and its analogues (1-3a). We observed that N-methyl-substituted immepip (methimepip) exhibits high affinity and agonist activity at the human histamine H3 receptor (pK i = 9.0 and pEC50 = 9.5) with a 2000-fold selectivity at the human H3 receptor over the human H4 receptor and more than a 10000-fold selectivity over the human histamine H1 and H 2 receptors. Methimepip was also very effective as an H3 receptor agonist at the guinea pig ileum (pD2 = 8.26). Moreover, in vivo microdialysis (in rat brain) showed that methimepip reduces the basal level of brain histamine to about 25% after a 5 mg/kg intraperitoneal administration.
