15109-97-4

Upstream product

• 1192-62-7 1-(2-furyl)-1-ethanone 
• 15109-94-1 1-(2-furyl)-2-bromoethanone 
• 603-35-0 triphenylphosphine 

Downstream Products

• 193196-97-3 (E)-5-Furan-2-yl-5-oxo-2-(triphenyl-λ⁵-phosphanylidene)-pent-3-enoic acid methyl ester 
• 193197-03-4 (E)-2-((Z)-3-Furan-2-yl-3-oxo-1-trifluoromethyl-propenyl)-4-(triphenyl-λ⁵-phosphanylidene)-pent-2-enedioic acid dimethyl ester 
• 193197-04-5 (E)-2-{2,2,3,3,4,4,4-Heptafluoro-1-[2-furan-2-yl-2-oxo-eth-(Z)-ylidene]-butyl}-4-(triphenyl-λ⁵-phosphanylidene)-pent-2-enedioic acid dimethyl ester 
• 1777-60-2 [(furan-2-ylcarbonyl)methylene]triphenylphosphorane 
• 117937-17-4 ethyl (E)-4-(furan-2-yl)-4-oxobut-2-enoate 
• 92-52-4 biphenyl 
• 1499198-35-4 4,4,4-trifluoro-1-(furan-2-yl)-3-phenylbutan-1-one 

Relevant academic research and scientific papers

Potassium 2-oxo-3-enoates as Effective and Versatile Surrogates for α, β-Unsaturated Aldehydes in NHC-Catalyzed Asymmetric Reactions

Potassium 2-oxo-3-enoates, which are readily prepared at scale and easily stored, have been found to be effective and versatile surrogates for α,β-unsaturated aldehydes in NHC-catalyzed asymmetric reactions. Promoted by chiral N-heterocyclic carbenes combined with LiCl, these easy-to-handle solid salts could release of CO2 and then undergo asymmetric reactions via homoenolate and α, β-unsaturated acyl azolium intermediate. The reactions have broad substrate scopes with high enantioselectivities. (Figure presented.).

Iodine-mediated intramolecular amination of ketones: The synthesis of 2-acylindoles and 2-acylindolines by tuning N-protecting groups

A general method for constructing both 2-acylindoles and 2-acylindolines via I2-mediated intramolecular C-N bond formation is presented, and the selective formation of either 2-acylindoles or 2-acylindolines just depends on the nitrogen protecting groups used in the same substrate skeletons. The Royal Society of Chemistry.

Highly efficient route to functionalized tetrahydrocarbazoles using a tandem cross-metathesis/intramolecular-hydroarylation sequence

The scope of the novel ruthenium-catalyzed tandem cross-metathesis/ intramolecular-hydroarylation sequence is described. This methodology offers a practical and efficient synthesis of structurally diverse and complex tetrahydrocarbazoles in good to excellent yields (up to 98%). Moreover, preliminary efforts towards the development of an enantioselective version of the current process by sequential catalysis with ruthenium complex and chiral amine are presented, with high yields and enantioselectivities (up to 88% yield and 91% ee).