16657-10-6

Usage

Uses

Used in Pharmaceutical Industry:
4-BROMO-2,3-DIHYDRO-1H-INDEN-1-OL is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs and enhance the properties of existing ones.
Used in Specialty Chemicals Production:
In the specialty chemicals industry, 4-BROMO-2,3-DIHYDRO-1H-INDEN-1-OL serves as a building block, facilitating the creation of unique and high-value chemical products.
Used in Agrochemicals Industry:
4-BROMO-2,3-DIHYDRO-1H-INDEN-1-OL is utilized as an intermediate in the production of agrochemicals, playing a role in the development of pesticides and other agricultural products.
Used in Fragrance and Flavor Industry:
4-BROMO-2,3-DIHYDRO-1H-INDEN-1-OL is used as a component in the manufacturing of fragrances and flavors, capitalizing on its unique aromatic characteristics to create appealing scents and tastes.
It is crucial to handle 4-BROMO-2,3-DIHYDRO-1H-INDEN-1-OL with caution due to its potential hazards to human health and the environment.

Upstream product

• 15115-60-3 4-bromo-2,3-dihydroinden-1-one 
• 15115-58-9 3-(2-bromophenyl)propionic acid 
• 58380-12-4 <(2-bromophenyl)methyl>propanedicarboxylic acid 
• 42287-90-1 3-(3-bromophenyl)propanoic acid 
• 335159-82-5 3-(m-bromophenyl)propionyl chloride 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 66192-11-8 diethyl 2-(2-bromobenzyl)propan-1,3-dioate 
• 90725-40-9 3-(2-bromophenyl)propanoyl chloride 

Downstream Products

• 16657-07-1 4-bromo-3H-indene 
• 45738-35-0 4-bromo-indene 
• 78383-18-3 4-phenyl-2,3-dihydro-1H-inden-1-ol 
• 1201447-21-3 5-(5-(1-hydroxy-2,3-dihydro-1H-inden-4-yl)oxazol-2-yl)-2-isopropoxybenzonitrile 
• 1307231-00-0 5-(5-(1-(tert-butyldimethylsilyloxy)-2,3-dihydro-1H-inden-4-yl)oxazol-2-yl)-2-isopropoxybenzonitrile 
• 1201447-23-5 5-(5-(1-(2-hydroxyethylamino)-2,3-dihydro-1H-inden-4-yl)oxazol-2-yl)-2-isopropoxybenzonitrile 
• 846032-36-8 4-bromo-1,3-dihydro-2H-inden-2-one 
• 125141-73-3 4-bromo-2,3-dihydro-1H-inden-2-ol 

Relevant academic research and scientific papers

Total Synthesis of Viridin and Viridiol

The asymmetric total synthesis of (-)-viridin and (-)-viridiol, antifungal metabolites, was achieved in 17 and 18 steps from a commercially available starting material. An intramolecular [3+2] cycloaddition was applied to an easily available l-ribose derivative in order to construct the highly substituted D ring containing the key chiral cis-triol fragment. Co-catalyzed metal-hydride H atom transfer (MHAT) radical cyclization was utilized to form the C-ring and the all-carbon quaternary center at C-10. This convergent strategy provides a scalable approach to prepare viridin and viridiol for biological studies.

FUSED PYRAZOLE AND IMIDAZOLE BASED COMPOUNDS AND USE THEREOF AS GLI1 INHIBITORS

The present invention is directed to a composition and a method for use thereof, such as for the treatment and prevention of a neurological disorder or cancer in a subject.

S1P1 AGONIST AND APPLICATION THEREOF

The present invention relates to a class of tricyclic compounds and an application thereof as a sphingosine 1-phosphate type 1 (S1P1) receptor agonist. The invention specifically relates to a compound represented by formula (II), and a tautomer and pharmaceutically acceptable salt of same.

Enantioselective Synthesis of Chiral Indane Derivatives by Rhodium-Catalyzed Addition of Arylboron Reagents to Substituted Indenes

Rhodium-catalyzed asymmetric addition of arylboron reagents to indene derivatives proceeded to give 2-arylindanes in good yields with high enantioselectivity. Deuterium-labeling experiments indicated that the present reaction involved a 1,4-Rh shift from an initially formed benzylrhodium to an arylrhodium intermediate before protonation leading to the corresponding addition product. The asymmetric addition was also successful for acenaphthylene, which has a similar skeleton to indene, where it was found that the benzylrhodium intermediate underwent direct protonation without the 1,4-Rh shift.

Aromatic ring-containing compound and application thereof

The present invention discloses an aromatic ring-containing compound and an application thereof, and provides an aromatic ring-containing compound represented by formula I, and a pharmaceutically acceptable salt, a hydrate, a solvate, a metabolite, a ster

Asymmetric Magnesium-Catalyzed Hydroboration by Metal-Ligand Cooperative Catalysis

Asymmetric catalysis with readily available, cheap, and non-toxic alkaline earth metal catalysts represents a sustainable alternative to conventional synthesis methodologies. In this context, we describe the development of a first MgII-catalyzed enantioselective hydroboration providing the products with excellent yields and enantioselectivities. NMR spectroscopy studies and DFT calculations provide insights into the reaction mechanism and the origin of the enantioselectivity which can be explained by a metal-ligand cooperative catalysis pathway involving a non-innocent ligand.

Metallocenes and catalyst compositions derived therefrom

This invention relates to a novel group 2, 3 or 4 transition metal metallocene catalyst compound that is asymmetric having two non-identical indenyl ligands with substitution at R2 having a branched or unbranched C1-C20 alkyl group substituted with a cyclic group or a cyclic group, R8 is an alkyl group and R4 and R10 are substituted phenyl groups.

Metallocenes and Catalyst Compositions Derived Tehrefrom

This invention relates to a novel group 2, 3 or 4 transition metal metallocene catalyst compound that is asymmetric having two non-identical indenyl ligands with substitution at R2 having a branched or unbranched C1-C20 alkyl group substituted with a cyclic group or a cyclic group, R8 is an alkyl group and R4 and R10 are substituted phenyl groups.

BRIDGED BIS(INDENYL) TRANSITIONAL METAL COMPLEXES, PRODUCTION, AND USE THEREOF

The invention relates to a novel group bridged metallocene transition metal complexes, wherein the complex includes at least one indenyl ligand substituted at the 4- position with a phenyl group, the 4-phenyl group being preferably substituted at the 3 ', 4', and 5' positions with particular combinations of substituents, particularly wherein the 4'- substituent is a group of the formula (XR'n)-, wherein X is a Group 14-17 heteroatom having an atomic weight of 13 to 79 and R' is one of a hydrogen atom, halogen atom, a C1-C10 alkyl group, or a C6-C10 aryl group and n is 0, 1, 2, or 3. Catalyst systems including the transition metal complex, polymerization processes using the transition metal complex, and polymers made using the transition metal complex are also described.

SELECTIVE HETEROCYCLIC SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS

Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.