15116-14-0Relevant academic research and scientific papers
IMIDAZOLE CARBOXAMIDES
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Page/Page column 7, (2010/02/17)
The present invention provides certain imidazole carboxamide derivatives, pharmaceutical compositions thereof, methods of using the same and processes for preparing the same.
Synthesis and lipase-mediated stereoselective deacetylation of (±)-3-acetoxymethyl-3-alkyl-7-methoxychroman-4-ones
Poonam,Prasad, Ashok K,Azim, Abul,Kumar, Rajesh,Jain, Subhash C,Parmar, Virinder S,Olsen, Carl E,Errington, William
, p. 7395 - 7402 (2007/10/03)
Six (±)-3-acetoxymethyl-3-alkyl-7-methoxychroman-4-ones have been synthesized in four steps starting with the coupling of resorcinol with corresponding aliphatic acid leading to the formation of 2,4-dihydroxyphenyl alkyl ketones, which upon monomethylation and hydroxymethylation, followed by acetylation afforded the racemic acetoxymethylated compounds in 17-30% overall yields. Candida rugosa lipase-catalyzed deacetylation of (±)-3-acetoxymethylchromanones in diisopropyl ether exhibited fairly moderate enantioselectivity.
Polyhydroxyphenol derivatives and preventive and therapeutic agents for bone and cartilage diseases containing the same
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, (2008/06/13)
Compounds useful as preventive and therapeutic agents for bone and cartilage diseases; and drug compositions containing the same. The compounds are polyhydroxyphenol derivatives of general formula (I) and quinione analogues derived therefrom (wherein Rsu
Lipase-catalysed regio- and enantioselective deacetylation of 2,4-diacetoxyphenyl alkyl ketones
Prasad, Ashok K.,Pati, Hari N.,Azim, Abul,Trikha, Smriti,Poonam
, p. 1973 - 1977 (2007/10/03)
Porcine pancreatic lipase in tetrahydrofuran catalyses the deacetylation of 2,4-diacetoxyphenyl alkyl ketones in a highly regioselective fashion. The strategy of regioselective deacetylation of diacetoxyphenyl alkyl ketones has also resulted in the enanti
