15117-33-6

Basic information

• Product Name: 5-(naphthalen-1-yl)-2-phenyloxazole
• Synonyms: 5-(naphthalen-1-yl)-2-phenyloxazole
• CAS NO: 15117-33-6
• Molecular Weight: 271.318
• Mol File: 15117-33-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 5-(naphthalen-1-yl)-2-phenyloxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(naphthalen-1-yl)-2-phenyloxazole(15117-33-6)
• EPA Substance Registry System: 5-(naphthalen-1-yl)-2-phenyloxazole(15117-33-6)

Safety Data

• Hazardous Substances Data: 15117-33-6(Hazardous Substances Data)

Upstream product

• 826-74-4 1-vinylnaphthalene 
• 100-46-9 benzylamine 
• 16208-20-1 2-(naphthalen-1-yl)-2-oxoacetaldehyde hydrate 
• 13686-51-6 2-bromoaceto-1-naphthone 
• 941-98-0 1'-naphthacetophenone 
• 2835-06-5 phenylglycin 
• 2996-92-1 phenyl trimethylsiloxane 
• 91804-15-8 5-(naphthalen-1-yl)oxazole 
• 20662-88-8 2-phenyloxazole 
• 90-14-2 1-Iodonaphthalene 
• 1199-01-5 2-phenylazlactone 
• 91-20-3 naphthalene 
• 37009-56-6 N-(2-[1]naphthyl-2-oxo-ethyl)-benzamide 

Downstream Products

• 1260140-55-3 5-(naphthalen-1-yl)-2-(1,2,3,4,5,6,7,8-octaphenylanthracen-9-yl)oxazole 

Relevant articles and documents

One-pot Friedel-Crafts/Robinson-Gabriel synthesis of oxazoles using oxazolone templates

We report herein a one-pot synthesis of 2,4,5-trisubstituted oxazoles via a Friedel-Crafts/Robinson-Gabriel synthesis using a general oxazolone template. Treatment of the oxazolone template with a range of aromatic nucleophiles provided the highly substituted oxazoles in good yields.

I2/TBHP-mediated domino process: A convenient route to 1,3-oxazole derivatives

A practical and simple synthesis of 2,5-disubstituted oxazoles was developed via a TBHP (tert-butyl hydroperoxide)/I2-mediated domino strategy. The reaction proceeds in series, giving rise to the formation of an intermolecular C-N bond and an intramolecular C-O bond, which yield oxazole derivatives simultaneously. The reaction gave the desired products from readily available substrates under mild conditions.

Metal-free dual sp3 C-H functionalization: I2- promoted domino oxidative cyclization to construct 2,5-disubstituted oxazoles

An I2-promoted sp3 C-H functionalization has been developed for the synthesis of 2,5-disubstituted oxazoles from easily available methyl ketones and benzylamines without any metal and peroxide catalyst. This domino oxidative cyclization process involves the cleavage of C-H bond and the formation of C-N, C-O bonds.