15121-71-8Relevant academic research and scientific papers
Highly Chemo- And Enantioselective Hydrogenation of 2-Substituted-4-oxo-2-alkenoic Acids
Chen, Weiping,Jiang, Ru,Liu, Xian,Nie, Huifang,Wen, Jialin,Yao, Lin,Zhang, Xumu
supporting information, (2020/07/02)
The highly chemo- and enantioselective hydrogenation of (E)-2-substituted-4-oxo-2-alkenoic acids was established for the first time using the Rh/JosiPhos complex, affording a series of chiral α-substituted-γ-keto acids with excellent results (up to 99% yield and >99% ee) and high efficiency (up to 3000 TON). In addition, the importance of this methodology was further demonstrated by a concise and gram-scale synthesis of the anti-inflammatory drug (R)-flobufen.
Carboxypeptidase A Catalyzed α,β-Elimination Reactions: Rapid Catalysis of α,β-Elimination of Hydrogen Chloride from β-Chloro Ketone Substrates
Nashed, Nashaat T.,Kaiser, E. T.
, p. 2710 - 2715 (2007/10/02)
The proteolytic enzyme carboxypeptidase A (CPA) catalyzes α,β-elimination of hydrogen chloride from 2-benzyl-2-chloro-3-(4-methoxybenzoyl)propionic acid (I), 2-benzyl-2-chloro-3-benzoylpropionic acid (II), and 2-chloro-2-methyl-3-benzoylpropionic acid (II
