91909-83-0Relevant academic research and scientific papers
A robust multifunctional ligand-controlled palladium-catalyzed carbonylation reaction in water
Gao, Pei-Sen,Zhang, Kan,Yang, Ming-Ming,Xu, Shan,Sun, Hua-Ming,Zhang, Jin-Lei,Gao, Zi-Wei,Zhang, Wei-Qiang,Xu, Li-Wen
supporting information, p. 5074 - 5077 (2018/05/26)
A novel, hydrophilic and recyclable methoxypolyethylene glycol (PEG)-modulated s-triazine-based multifunctional Schiff base/N,P-ligand L9 was prepared and used in Pd-catalyzed Heck-type carbonylative coupling reactions, affording diverse chalcone derivatives and 1,4-dicarbonyl esters in good yields.
The in situ oxidation-Wittig reaction of α-hydroxyketones
Runcie, Karen A.,Taylor, Richard J. K.
, p. 974 - 975 (2007/10/03)
In situ oxidation-Wittig methodology has been applied to α-hydroxyketones avoiding the problems normally associated with α-ketoaldehydes; the procedure is practically simple, and in many cases gives high yields of the product γ-ketocrotonates; the procedu
REACTIONS RELATED TO COENZYME B12 DEPENDENT REARRANGEMENTS: METAL MEDIATED FREE RADICAL ACYL MIGRATIONS IN METHYL AND CYCLOPROPYL SUBSTITUTED MODELS
Best, Wayne M.,Widdowson, David A.
, p. 5943 - 5954 (2007/10/02)
Free radicals generated from the methylmalonylcoenzyme A mutase model substrates (3) and (4) by chromium(II) reduction, or by pyrolysis of the analogous cobaloximes, underwent -migration only in the acyl series (R=Ph, Me) and not the critical ester series (R=OEt, SBu).The mechanism of the migration was implied by incorporation into (4) of the cyclopropyl ring, the opening of which demonstrated the free radical nature of rearranged intermediate.
Reactions Potentially Related to Coenzyme B12 Dependent Rearrangements: Observations on the Radical -Acyl and -Thiol Ester Migrations
Best, Wayne M.,Cook, Anthony P. F.,Russell, James J.,Widdowson, David A.
, p. 1139 - 1144 (2007/10/02)
Reaction of 2-iodomethyl-2-methyl-3-oxo esters with tributyltin radicals, generated photochemically from hexabutylditin or tributyltin hydride in cyclohexane, or benzene-acetonitrile, resulted in a -acyl migration in 10-63percent yields dependent on the source of tin radical and substrate used.Radical migration was confirmed by the use of tributyltin deuteride.Thiol ester group migration was not observed.A new, highly efficient method for thiol ester synthesis is described.
Carboxypeptidase A Catalyzed α,β-Elimination Reactions: Rapid Catalysis of α,β-Elimination of Hydrogen Chloride from β-Chloro Ketone Substrates
Nashed, Nashaat T.,Kaiser, E. T.
, p. 2710 - 2715 (2007/10/02)
The proteolytic enzyme carboxypeptidase A (CPA) catalyzes α,β-elimination of hydrogen chloride from 2-benzyl-2-chloro-3-(4-methoxybenzoyl)propionic acid (I), 2-benzyl-2-chloro-3-benzoylpropionic acid (II), and 2-chloro-2-methyl-3-benzoylpropionic acid (II
