151264-96-9Relevant academic research and scientific papers
Proline-based N-oxides as readily available and modular chiral catalysts. Enantioselective reactions of allyltrichlorosilane with aldehydes
Traverse, John F.,Zhao, Yu,Hoveyda, Amir H.,Snapper, Marc L.
, p. 3151 - 3154 (2005)
(Chemical Equation Presented) A proline-based N-oxide is identified that serves as an effective catalyst for the reaction of allyltrichlorosilane with aryl and α,β-unsaturated aldehydes at room temperature to afford the desired homoallylic alcohols in up to 92% ee. The chiral catalyst can be easily prepared from optically pure proline in three simple steps and 60% overall yield.
