15128-91-3

Usage

Uses

Used in Pharmaceutical Industry:
2,6-DINITRO-3-HYDROXYPYRIDINE is used as a reagent for the synthesis of pyrimidinediamine derivatives. These derivatives have the potential to act as Syk protease inhibitors, which are important targets for drug development. Inhibiting Syk protease can be beneficial in the treatment of various diseases, as it plays a role in the regulation of immune responses and inflammatory processes.
In the context of drug development, 2,6-DINITRO-3-HYDROXYPYRIDINE serves as a key intermediate in the synthesis of compounds that can modulate the activity of Syk protease. By targeting this enzyme, these synthesized compounds may help in the development of novel therapeutics for a range of diseases, including autoimmune disorders and inflammatory conditions.

InChI:InChI=1/C5H3N3O5/c9-3-1-2-4(7(10)11)6-5(3)8(12)13/h1-2,9H

Upstream product

• 15128-82-2 3-hydroxy-2-nitropyridine 
• 17747-43-2 3-pyridyl acetate 
• 108-24-7 acetic anhydride 

Downstream Products

• 101079-67-8 3-chloro-2,6-dinitro-pyridine 
• 52092-47-4 5-chloro-2-nitropyridine 
• 1072-98-6 5-chloro-2-pyridylamine 

Relevant academic research and scientific papers

Reactivity of heterocyclic compounds in nitration. 8. Nitration of 3-hydroxypyridine and its substituted forms

Nitration of 3-hydroxypyridine and its substituted forms has been studied under various conditions. It is shown that, depending on the reaction temperature and the nitrating agent, the end products of the synthesis can be 3-hydroxy-2,6-dinitropyridine or 3-hydroxy-2,4,6-trinitropyridine. The possibility of substitutional nitration of iodine derivatives of 2- and 3-hydroxypyridine is demonstrated. 1999 Kluwer Academic/Plenum Publishers.

COMPOUNDS USEFUL TO TREAT PAIN

The present invention relates to compounds useful as bradykinin receptor antagonist, pharmaceutical composition comprising such compounds, and therapeutic use of the same. The present invention further relates to the combination of compounds useful for the therapeutic use. The present invention relates to the pharmaceutical composition comprising the compound and combination of compounds useful for treatment of urinary bladder pain, the symptomatic relief of pain, burning, urgency, frequency, and other discomforts arising from irritation of the lower urinary tract mucosa caused by infection, trauma, surgery, endoscopic procedures, or the passage of sounds or catheters.