1512840-48-0Relevant academic research and scientific papers
Copper-catalyzed intermolecular cyanotrifluoromethylation of alkenes: Convenient synthesis of CF3-containing alkyl nitriles
Liang, Zhaoli,Wang, Fei,Chen, Pinhong,Liu, Guosheng
, p. 55 - 60 (2014)
A copper-catalyzed intermolecular cyanotrifluoromethylation of alkenes has been developed, in which the less reactive Togni reagent 2 was used as a CF3 source and TMSCN was employed as a cyano source. Both activated and unactivated alkenes were suitable for this transformation to give CF3-containing organonitriles under mild conditions.
A Readily Available Trifluoromethylation Reagent and Its Difunctionalization of Alkenes
Zhang, Min,Lin, Jin-Hong,Xiao, Ji-Chang
supporting information, p. 6079 - 6083 (2021/08/16)
Trifluoromethyl substitution is notably popular in pharmaceuticals and agrochemicals; however, trifluoromethylated compounds normally rely on the use of cost-prohibitive or gaseous trifluoromethylating reagents, which diminishes the general applicability of these methods. Herein an efficient trifluoromethylation reagent trifluoromethylsulfonyl-pyridinium salt (TFSP) was reported, which can be readily prepared from cheap and easily available bulk industrial feedstocks. TFSP can generate a trifluoromethyl radical under photocatalysis and realize the effective azido- or cyano-trifluoromethylation reactions of alkenes.
Copper-catalyzed intermolecular cyanotrifluoromethylation of alkenes
He, Yu-Tao,Li, Lian-Hua,Yang, Yan-Fang,Zhou, Zhao-Zhao,Hua, Hui-Liang,Liu, Xue-Yuan,Liang, Yong-Min
supporting information, p. 270 - 273 (2014/01/23)
A novel and highly practical reaction for the copper-catalyzed intermolecular cyanotrifluoromethylation of alkenes is presented here. This methodology provides a general and straightforward way to synthesize a variety of useful CF3-containing nitriles, which can be used for further preparation of pharmaceutically and agrochemically important compounds in synthetic organic chemistry.
