151291-56-4Relevant academic research and scientific papers
Cu-Catalyzed Cross-Dehydrogenative ortho-Aminomethylation of Phenols
Yu, Congjun,Patureau, Frederic W.
, p. 11807 - 11811 (2018)
A highly selective CuII-catalyzed cross-dehydrogenative ortho-aminomethylation of phenols with aniline derivatives is described. The corresponding C(sp2)?C(sp3) coupling products were obtained in moderate to excellent yields under mild reaction conditions and with a broad substrate scope. A radical mechanism is proposed.
Cr-Catalyzed Direct ortho-Aminomethylation of Phenols
Shi, Junbin,Wang, Yubin,Bu, Qingqing,Liu, Binyuan,Dai, Bin,Liu, Ning
, p. 17567 - 17580 (2021/12/17)
We developed a Cr-catalyzed strategy for the regioselective formation of Csp2–Csp3 bonds through the direct and efficient ortho-aminomethylation of N,N-dimethylanilines with phenols. The approach showed excellent site selectivity at the ortho-position of phenols and accommodated broad substrate scope and functional group compatibility for both N,N-dimethylanilines and phenols. Mechanistic studies revealed that the direct ortho-aminomethylation between N,N-dimethylanilines and phenols occurred via an ionic mechanism.
Nickel Catalyzed Ipso-hydroxylation and Subsequent Cross Dehydrogenative Coupling of Arylboronic Acids with Tertiary Amines: A Facile Access to α-phenolated Tertiary Amines
Kumar, Promod,Kumar Sharma, Anup,Singh, Rahul,Guntreddi, Tirumaleswararao,Nand Singh, Krishna
supporting information, p. 1786 - 1789 (2018/03/28)
A straightforward and new approach has been developed for the α-functionalization of tertiary amines via sequential oxidative hydoxylation and cross-dehydrogenative coupling (CDC) of arylboronic acids with tertiary amines to afford α-phenolated tertiary amines. The results demonstrate an easy arylation of C(sp3)?H bond in the presence of an inexpensive and readily available nickel metal salt. (Figure presented.).
Metal-Free Diaryl Etherification of Tertiary Amines by Ortho-C(sp2)-H Functionalization for Synthesis of Dibenzoxazepines and -ones
Jamsheena, Vellekkatt,Mahesha, Chikkagundagal K.,Joy, M. Nibin,Lankalapalli, Ravi S.
supporting information, p. 6614 - 6617 (2017/12/26)
A phenyliodine(III) diacetate mediated umpolung reactivity of the tertiary amines with suitably substituted o-hydroxybenzyl and phenyl groups is exploited to facilitate o-C(sp2)-H functionalization to afford diaryl ethers. The presence of an o-
Palladium-Catalyzed Regioselective C-Benzylation via a Rearrangement Reaction: Access to Benzyl-Substituted Anilines
Amézquita-Valencia, Manuel,Alper, Howard
, p. 16774 - 16778 (2016/11/17)
An unprecedented C-benzylation rearrangement reaction, catalyzed by palladium, is reported. The reaction proceeds by rearrangement leading to the direct synthesis of para or ortho benzyl-substituted N-methylanilines. The product is obtained in high regioselectivity, without the need to use a ligand for the catalytic process.
