1513-70-8 Usage
Uses
Used in Pharmaceutical Industry:
4(3H)-PYRIMIDINONE, 6-AMINO-2-(TRIFLUOROMETHYL)is used as a building block for the synthesis of pharmaceuticals due to its unique structure and properties. It contributes to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 4(3H)-PYRIMIDINONE, 6-AMINO-2-(TRIFLUOROMETHYL)serves as a key component in the synthesis of agrochemicals, helping to create new compounds with pesticidal or herbicidal properties to enhance crop protection and yield.
Used in Fluorinated Compounds Production:
4(3H)-PYRIMIDINONE, 6-AMINO-2-(TRIFLUOROMETHYL)is used as a valuable precursor in the production of fluorinated compounds. The presence of the trifluoromethyl group in its structure makes it an important building block for the development of various materials and chemicals that require fluorination.
Used in Research and Development:
Due to its unique structure and properties, 4(3H)-PYRIMIDINONE, 6-AMINO-2-(TRIFLUOROMETHYL)is a potential candidate for further research and development in medicinal and agricultural chemistry. It may lead to the discovery of new compounds with improved efficacy and selectivity for various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1513-70-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,5,1 and 3 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1513-70:
(6*1)+(5*5)+(4*1)+(3*3)+(2*7)+(1*0)=58
58 % 10 = 8
So 1513-70-8 is a valid CAS Registry Number.
InChI:InChI=1/C5H4F3N3O/c6-5(7,8)4-10-2(9)1-3(12)11-4/h1H,(H3,9,10,11,12)
1513-70-8Relevant academic research and scientific papers
Discovery of 6-phenylpyrimido[4,5- B ][1,4]oxazines as potent and selective Acyl CoA: Diacylglycerol acyltransferase 1 (DGAT1) inhibitors with in vivo efficacy in rodents
Fox, Brian M.,Sugimoto, Kazuyuki,Iio, Kiyosei,Yoshida, Atsuhito,Zhang, Jian,Li, Kexue,Hao, Xiaolin,Labelle, Marc,Smith, Marie-Louise,Rubenstein, Steven M.,Ye, Guosen,McMinn, Dustin,Jackson, Simon,Choi, Rebekah,Shan, Bei,Ma, Ji,Miao, Shichang,Matsui, Takuya,Ogawa, Nobuya,Suzuki, Masahiro,Kobayashi, Akio,Ozeki, Hidekazu,Okuma, Chihiro,Ishii, Yukihito,Tomimoto, Daisuke,Furakawa, Noboru,Tanaka, Masahiro,Matsushita, Mutsuyoshi,Takahashi, Mitsuru,Inaba, Takashi,Sagawa, Shoichi,Kayser, Frank
supporting information, p. 3464 - 3483 (2014/05/20)
The discovery and optimization of a series of acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors based on a pyrimido[4,5-b][1,4]oxazine scaffold is described. The SAR of a moderately potent HTS hit was investigated resulting in the discovery of phenylcyclohexylacetic acid 1, which displayed good DGAT1 inhibitory activity, selectivity, and PK properties. During preclinical toxicity studies a metabolite of 1 was observed that was responsible for elevating the levels of liver enzymes ALT and AST. Subsequently, analogues were synthesized to preclude the formation of the toxic metabolite. This effort resulted in the discovery of spiroindane 42, which displayed significantly improved DGAT1 inhibition compared to 1. Spiroindane 42 was well tolerated in rodents in vivo, demonstrated efficacy in an oral triglyceride uptake study in mice, and had an acceptable safety profile in preclinical toxicity studies.
